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Preparation of Profibrinolysin-free Fibrinogen and Thrombin from Human Plasma

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Abstract

AMBRUS1 has described an in vitro assay for fibrinolytic enzymes and has correlated his results with the therapeutic effectiveness of the preparations tested. Both the fibrinogen and thrombin used in this assay must be free or nearly free of profibrinolysin in order to distinguish between fibrinolysin and profibrinolysin activator activity.

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References

  1. Ambrus, C. M., and Markus, G., Amer. J. Phys., 199, 491 (1960). Ambrus, J. L., Ambrus, C. M., Sokal, J. E., Markus, G., Back, N., Stutzman, L., Razis, D., Ross, C. A., Smith, B. H., Rekate, A. C., Collins, G. L., Kline, D. L., and Fishman, J. B., Amer. J. Cardiol., 6, 462 (1960).

    CAS  Google Scholar 

  2. Laki, K., Arch. Biochem., 28, 317 (1951).

    Article  Google Scholar 

  3. Celander, D. R., and Guest, M. M., Fed. Proc., 19, No. 1, 511 (1960).

    Google Scholar 

  4. Steinbuck, M. (personal communication).

  5. Seegers, W. H., and McGinty, D. A., J. Biol. Chem., 146, 511 (1942).

    CAS  Google Scholar 

  6. Milstone, H., J. Gen. Physiol., 25, 679 (1942).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Goldstein, R., LeBolloc'h, A., Alexander, B., and Zonderman, E., J. Biol. Chem., 234, 2857 (1959).

    CAS  PubMed  Google Scholar 

  8. Markus, G., and Ambrus, C. M., Nature, 188, 582 (1960).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Cohn, E. J., Strong, L. E., Hughes, jun., W. L., Mulford, D. J., Ashworth, J. N., Melin, M., and Taylor, H. L., J. Amer. Chem. Soc., 68, 459 (1946).

    Article  CAS  Google Scholar 

  10. Oncley, J. L., Melin, M., Richert, D. A., Cameron, J. W., and Gross, jun., P. M., J. Amer. Chem. Soc., 71, 541 (1949).

    Article  CAS  Google Scholar 

  11. Strong, L. E., Encyclopedia of Chemical Technology, 2, 571 (Inter-science Encyclopedia, Inc., New York, 1948).

    Google Scholar 

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Authors and Affiliations

  1. Protein Research Section, Cutter Laboratories, Berkeley, California

    JOHN H. HINK JUN. & J. KEN McDONALD

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  1. JOHN H. HINK JUN.
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  2. J. KEN McDONALD
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HINK, J., McDONALD, J. Preparation of Profibrinolysin-free Fibrinogen and Thrombin from Human Plasma. Nature 194, 1080–1081 (1962). https://doi.org/10.1038/1941080a0

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