Skip to main content
SpringerLink
Log in

Cytopathic Protective Factor: its Production by Normal Uninfected Serum-free Cell Cultures

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

AT the present time two well-defined systems of viral interference by cell products have been demonstrated in vitro. They are interferon1 and viral inhibitory factor2, the latter possibly being a variety of interferon. Both at least have in common the fact that they are produced in cell cultures infected with virus, active virus in the case of the latter, or inactivated where interferon is concerned. Other differences and similarities are discussed in a recent report by Ho and Enders3. It is well known that virus inhibitors are present in a variety of mammalian tissues and fluids4 and may be demonstrated either in vivo or in vitro.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Isaacs, A., and Lindemann, J., Proc. Roy. Soc., B, 147, 258 (1957).

    Article  ADS  CAS  Google Scholar 

  2. Ho, M., and Enders, J. F., Proc. U.S. Nat. Acad. Sci., 45, 385 (1959).

    Article  ADS  CAS  Google Scholar 

  3. Ho, M., and Enders, J. F., Virology, 9, 446 (1959).

    Article  CAS  Google Scholar 

  4. Tamm, I., and Horsfall, F. L., Proc. Soc. Exp. Biol. Med., 74, 108 (1950). McCrea, J. F., Biochem. J., 55, 132 (1953). Cohen, A., Lancet, 791 (1960). Low, R. J., and Baron, S., Science, 132, 622 (1960).

    Article  CAS  Google Scholar 

  5. Pumper, R. W., Science, 128, 363 (1958).

    Article  ADS  CAS  Google Scholar 

  6. Pumper, R. W., Alfred, L. J., and Sackett, D. L., Nature, 185, 123 (1960).

    Article  ADS  CAS  Google Scholar 

  7. Pumper, R. W., and Yamashiroya, H. M., Amer. J. Hyg., 72, 284 (1960).

    CAS  PubMed  Google Scholar 

  8. Alfred, L. J., and Pumper, R. W., Proc. Soc. Exp. Biol. Med., 103, 688 (1960).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology, College of Medicine, University of Illinois, Chicago

    ROBERT W. PUMPER, HERBERT M. YAMASHIROYA & LAWRENCE J. ALFRED

Authors
  1. ROBERT W. PUMPER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. HERBERT M. YAMASHIROYA
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. LAWRENCE J. ALFRED
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PUMPER, R., YAMASHIROYA, H. & ALFRED, L. Cytopathic Protective Factor: its Production by Normal Uninfected Serum-free Cell Cultures. Nature 192, 1101–1102 (1961). https://doi.org/10.1038/1921101a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1921101a0

  • Springer Nature Limited

Search

Navigation