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Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects

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Abstract

THE inhibitory action of guinea pig serum on the cells of three transplantable mouse and rat lymphomas in vivo was described some years ago in papers from this Laboratory1,2. In a continuation of this work, evidence has now been found that the L-asparaginase activity of guinea pig serum is responsible for the antilymphoma effect. The evidence has been obtained in two ways: first, by a study of the induction of resistance to guinea pig serum by 6C3HED cells grown in tissue culture; and secondly, by a direct comparison of L-asparaginase activity in various preparations of guinea pig serum with their tumour inhibitory properties.

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  1. Department of Pathology, Cornell University Medical College, 1300 York Avenue, New York, 21

    J. D. BROOME

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  1. J. D. BROOME
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BROOME, J. Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects. Nature 191, 1114–1115 (1961). https://doi.org/10.1038/1911114a0

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