Abstract
THE discovery by Hillarp and his colleagues1 of the presence of large amounts of adenosine triphosphate (ATP) in the adrenal medulla has led to speculations on its role in the storage and retention of catechol amines in this tissue. It has been shown that the amines are stored in cell organelles, the chromaffin granules, which are distinct from the mitochondria; they can be separated from the latter by centrifugation over a density gradient2. This has made it possible to establish that ATP occurs in a high concentration in the sites of storage of the catechol amines, in stoichiometric amounts in relation to the amines present.
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References
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PRUSOFF, W., BLASCHKO, H., ORD, M. et al. Incorporation of Phosphorus-32 into Adenosine Triphosphate of Adrenal Chromaffin Granules. Nature 190, 354–355 (1961). https://doi.org/10.1038/190354a0
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DOI: https://doi.org/10.1038/190354a0
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