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Exposing the human nude phenotype

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Abstract

The recent discovery of the human counterpart of the hairless mouse phenotype1 has helped our understanding of the molecular genetics of hair growth. But there are no reports of a defect in the human homologue of the best known of the ‘bald’ mouse phenotypes, the nude mouse2. This may be because affected individuals are so gravely ill from the accompanying immunodeficiency that their baldness goes unnoticed. We have carried out a genetic analysis that reveals a human homologue of the nude mouse.

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Figure 1: Molecular analysis of the human nude phenotype.

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Authors and Affiliations

  1. Departments of Dermatology, Columbia University, New York, 10032, New York, USA

    Jorge Frank, Andrei A. Panteleyev, Wasim Ahmad, Peter B. Cserhalmi-Friedman, Hendrik Uyttendaele & Angela M. Christiano

  2. Department of Pediatrics, Unit of Immunology, Federico II University, Naples, Italy

    Claudio Pignata, Lucia Gaetaniello & Nicola Pozzi

  3. Cutaneous Biology Research Center, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Charlestown, 02129, Massachusetts, USA

    David M. Prowse, Howard Baden, Lorin Weiner & Janice L. Brissette

  4. Genetics and Development, Columbia University, New York, 10032, New York, USA

    Vincent M. Aita & Angela M. Christiano

  5. Laboratory of Statistical Genetics, The Rockefeller University, New York, 10021, New York, USA

    Derek Gordon & Jurg Ott

Authors
  1. Jorge Frank
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  2. Claudio Pignata
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  3. Andrei A. Panteleyev
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  4. David M. Prowse
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  5. Howard Baden
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  6. Lorin Weiner
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  7. Lucia Gaetaniello
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  8. Wasim Ahmad
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  9. Nicola Pozzi
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  10. Peter B. Cserhalmi-Friedman
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  11. Vincent M. Aita
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  12. Hendrik Uyttendaele
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  13. Derek Gordon
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  14. Jurg Ott
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  15. Janice L. Brissette
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  16. Angela M. Christiano
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Frank, J., Pignata, C., Panteleyev, A. et al. Exposing the human nude phenotype. Nature 398, 473–474 (1999). https://doi.org/10.1038/18997

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