Abstract
THE opinion has been advanced that acetylcholine acts in the heart not only as the mediator of the vagus nerve but also as the so-called local hormone in local extraneural regulation of heart activity and that in this last function it is closely associated with heart automation1. If this view is correct, it can be assumed that the most rapid turnover of acetylcholine will occur in those parts of the heart which possess the highest degree of automation. In order to verify the correctness of this assumption, experiments were carried out in which the distribution of acetylcholine and cholinesterase in different parts of white rat heart was examined.
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VLK, J., TUČEK, S. & HABERMANN, V. Distribution of Acetylcholine and Cholinesterase in the Heart of White Rats. Nature 189, 923–924 (1961). https://doi.org/10.1038/189923b0
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DOI: https://doi.org/10.1038/189923b0
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