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Fatty Acid and Glucose Metabolism in the Perfused Heart

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Abstract

PREVIOUS work on intact animals in which arteriovenous differences across the myocardium were measured1,2 have suggested that fatty acids are an important metabolite for the heart. No work has been reported on the isolated heart with radioisotopes which allow a separation of the uptake and fate of a particular substrate. This communication gives an account of the uptake and certain metabolic fates of fatty acid and glucose in the isolated, perfused heart. The results indicate the readiness with which the myocardium utilizes both glucose and fatty acids, and suggest that fatty acids are preferentially oxidized. The latter observation provides a possible explanation for the puzzling increase in cardiac glycogen known to occur with fasting or with untreated diabetes.

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References

  1. Ballard, F. B., Danforth, W. H., Naegle, S., and Bing, R. J., J. Clin. Invest., 39, 717 (1960).

    Article  CAS  Google Scholar 

  2. Gordon, jun., R. S., and Cherkes, A., J. Clin. Invest., 36, 810 (1957).

    Article  CAS  Google Scholar 

  3. Bleehen, N. M., and Fisher, R. B., J. Physiol., 123, 260 (1954).

    Article  CAS  Google Scholar 

  4. Morgan, H. E., Henderson, M. J., Regen, D. M., and Park, C. R., J. Biol. Chem., 236, 253 (1961).

    CAS  PubMed  Google Scholar 

  5. Winegrad, A. I., and Renold, A. E., J. Biol. Chem., 233, 267 (1958).

    CAS  Google Scholar 

  6. Horn, H. D., and Bruns, F. H., Biochim. Biophys. Acta, 21, 378 (1956).

    Article  CAS  Google Scholar 

  7. MacLeod, J. J. R., and Prendergast, D. J., Trans. Roy. Soc. Canada, Sect. V, 15, 37 (1921).

    CAS  Google Scholar 

  8. Cruickshank, E. W. H., J. Physiol., 47, 1 (1913).

    Article  CAS  Google Scholar 

  9. Russell, Jane A., and Bloom, W., Endocrinol., 58, 83 (1956).

    Article  CAS  Google Scholar 

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Author notes

  1. JOSEPH C. SHIPP

    Present address: School of Medicine, University of Florida, Gainesville

Authors and Affiliations

  1. Department of Medicine, Harvard Medical School,

    JOSEPH C. SHIPP, LIONEL H. OPIE & DAVID CHALLONER

  2. Peter Bent Brigham Hospital and Baker Clinic Research Laboratory, Boston, Mass.

    JOSEPH C. SHIPP, LIONEL H. OPIE & DAVID CHALLONER

Authors
  1. JOSEPH C. SHIPP
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  2. LIONEL H. OPIE
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  3. DAVID CHALLONER
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SHIPP, J., OPIE, L. & CHALLONER, D. Fatty Acid and Glucose Metabolism in the Perfused Heart. Nature 189, 1018–1019 (1961). https://doi.org/10.1038/1891018a0

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