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Formation of a New Metabolite of Epinephrine and Norepinephrine in Liver and Kidney

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Abstract

IN previous work it was found that after the injection of norepinephrine and epinephrine in rats, a new metabolite of these compounds was excreted in the urine1. Axelrod et al. 2 have isolated recently from the urine of rats a metabolite of epinephrine and norepinephrine, which they have identified as 3-methoxy-4-hydroxy phenyl glycol. We have found that after the intravenous infusion in cats of a mixture containing both norepinephrine-7-3H and epinephrine-1-14C, a similar compound was found in the liver and kidney of this animal.

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References

  1. Goldstein, M., Friedhoff, A. J., and Sandler, G., Experientia (in the press).

  2. Axelrod, J., Kopin, I. J., and Mann, J. D., Biochim. Biophys. Acta 36, 576 (1959).

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  3. Bertler, A., Carlsson, A., and Rosengren, E., Acta Physiol. Scand., 44, 273 (1958).

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  4. Bush, I. E., Biochem. J., 270 (1951).

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Authors and Affiliations

  1. New York University School of Medicine, and Seton Hall College of Medicine, Jersey City

    M. GOLDSTEIN & S. B. GERTNER

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  1. M. GOLDSTEIN
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  2. S. B. GERTNER
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GOLDSTEIN, M., GERTNER, S. Formation of a New Metabolite of Epinephrine and Norepinephrine in Liver and Kidney. Nature 187, 147–148 (1960). https://doi.org/10.1038/187147a0

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