Abstract
Norepinephrine (NE), epinephrine (E), and dopamine are the naturally occurring biologically important catecholamines. E is the circulating hormone of the adrenal medulla, regulated by impulse traffic in the splanchnic nerves; NE is the adrenergic neurotransmitter released from peripheral sympathetic nerve endings in response to a downward flow of impulses from the sympathetic centers in the brainstem; and DA is formed in peripheral tissues from the decarboxylation of circulating DOPA. The physiologic effects of the catecholamines are mediated by cell surface receptors on effector cells. The excessive production of these compounds in pheochromocytomas and paragangliomas is responsible for the clinical manifestations of these tumors.
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References
Landsberg L. Catecholamines; Philadelphia: Wolters-Kluwer; 2017.
Young JB, Landsberg L. Chapter 13. Physiology of the sympathoadrenal system. In: Williams textbook. Philadelphia: 9th ed. Saunders; 1998.
Hall AK, Principal Neurons LSC. Small intensely fluorescent (SIF) cells in the rat superior cervical ganglion have distinct developmental histories. J Neurosci. 1991;11:472–84.
Carey RM. Chapter 45. Dopamine mechanisms in the kidney. In: Primer on the autonomic nervous system. Amsterdam: Elsevier Inc; 2012. p. 221–3.
Winkler H. The adrenal chromaffin granule: a model for large dense core vesicles of endocrine and nervous tissue. J Anat. 1993;183:237–52.
Benarroch EE. Chapter 2. Central autonomic control. In: Primer on the autonomic nervous system; Amsterdam: Acdamic press (Elsevier) 2012. p. 9–12.
Morrison SF. Differential control of sympathetic outflow. Am J Physiol Regulatory Integrative Comp Physiol. 2001;281:R683–98.
Westfall TC, Westfall DP. Neurotransmission: the autonomic and somatic motor nervous systems. In: Goodman & Gilman’s the pharmacological basis of therapeutics. New York: McGraw Hill; 2011.
Gilman AG. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56:615–49.
Tobin AB. G-protein-coupled receptor phosphorylation: where, when and by whom. Br J Pharmacol. 2008;153(suppl 1):S167–S176.
Kohout TA, Lefkowitz RJ. Regulation of G protein-coupled receptor kinases and Arrestins during receptor desensitization. Mol Pharmacol. 2003;63:9–18.
Westfall TC, Westfall DP. Adrenergic agonists and antagonists. In: Goodman & Gilman’s the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill; 2011.
Coppack SW, Jensen MD, Miles JM. In vivo regulation of lipolysis in humans. J Lipid Res. 1994;35:177–86.
Enerbäck S. Brown adipose tissue in humans. Int J Obes. 2010;34:S43–6.
Morrison SF, Madden CJ, Tupone D. Central control of brown adipose tissue thermogenesis. Front Endocrinol. 2012;3:1–19.
Ricquier D. Uncoupling protein 1 of brown adipocytes, the only uncoupler: a historical perspective. Front Endocrinol. 2011;2:1–7.
Landsberg L, Young JB. Catecholamines and the adrenal medulla. In: Bondy PK, Rosenberg LE, et al., editors. Metabolic control and disease. 8th ed. Philadelphia: W.B. Saunders; 1980. p. 1621–93.
Landsberg L. Catecholamines and the sympathoadrenal system. In: Ingbar SH, editor. The year in endocrinology. New York: Plenum; 1976. p. 177–231.
Young JB, Landsberg L. Obesity and circulation. In: Sleight P, et al., editors. Scientific foundations of cardiology. London: Heineman; 1983.
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Landsberg, L. (2018). Catecholamines. In: Landsberg, L. (eds) Pheochromocytomas, Paragangliomas and Disorders of the Sympathoadrenal System. Contemporary Endocrinology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-77048-2_1
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