Skip to main content
SpringerLink
Log in

Runt Disease and Tolerance in Rabbits

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE production of immunological tolerance, that is, specific inhibition of the immune response in adult life by contact with antigen at an early age, was first described by Billingham, Brent and Medawar1 and Hašek2. By this means, animals of different strains or breeds can be made to accept skin homografts from each other in adult life, provided they have been injected in the fœtal or early neonatal period with cells taken from their future skin donors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Billingham, R. E., Brent, L., and Medawar, P. B., Nature, 172, 603 (1953).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Hašek, M., Csl. Biol., 2, 25 (1953).

    Google Scholar 

  3. Woodruff, M. F. A., and Simpson, L. O., Brit. J. Exp. Path., 36, 494 (1955).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Billingham, R. E., and Brent, L., Transpl. Bull., 4, 67 (1957).

    CAS  PubMed  Google Scholar 

  5. Billingham, R. E., Brent, L., and Medawar, P. B., Phil. Trans., B, 239, 357 (1956).

    Article  Google Scholar 

  6. Stark, R. B., Brownlee, H., and Grunwald, R. P., Ann. N.Y. Acad. Sci., 73, 772 (1958).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Medawar, P. B., J. Anat., 78, 176 (1944).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, St. Mary's Hospital, London, W.2

    K. A. PORTER

Authors
  1. K. A. PORTER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PORTER, K. Runt Disease and Tolerance in Rabbits. Nature 185, 789–790 (1960). https://doi.org/10.1038/185789a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/185789a0

  • Springer Nature Limited

This article is cited by

Search

Navigation