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Splenic Siderosis in Mice Treated with Dithiourethane

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Abstract

IN an attempt to elucidate the mode of action of urethane (ethyl carbamate) as a carcinogen for mice, its dithio analogue (NH2CSSC2H5) was prepared1,2 and a study was made of its lethal dose and general toxic effects before testing it for carcinogenicity. A report of the latter is in preparation. The short-term tests revealed an action of this compound whose significance is, at the moment, rather obscure.

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References

  1. Campbell, N., and McKail, J. E., J. Chem. Soc., Part II, 1251 (1948).

  2. Delépine, M., Bull. Soc. chim. Paris, 29, 48 (1903).

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Authors and Affiliations

  1. Dept. of Pharmacology, Guy's Hospital Medical School, London, S.E.1

    P. N. COWEN

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  1. P. N. COWEN
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COWEN, P. Splenic Siderosis in Mice Treated with Dithiourethane. Nature 184, 366–367 (1959). https://doi.org/10.1038/184366b0

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