Abstract
As described in previous papers1, our experimental results, using the method of Moore and Stein2, have shown that the amino-acid composition of whale (sei-) insulin differs from that reported by Sanger et al. 3. Furthermore, we have recently re-examined the amino-acid analyses of sperm- and sei-whale insulins (whole insulin and both glycyl (A) and phenylalanyl (B) chains of oxidized insulin, respectively). These experiments have confirmed that the amino-acid content of sperm insulin is similar to that obtained by Sanger et al.; but sei-whale insulin contains an alanine instead of an isoleucine residue in the A chain.
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References
Saito, T., Ishihara, Y., Ito, Y., and Fujino, M., Bull. Fac. Fish. Hokkaido Univ. Japan, 8, 54 (1957).
Moore, S., and Stein, W. H., J. Biol. Chem., 192, 663 (1951).
Harris, J. I., Sanger, F., and Naughton, M. A., Arch. Biochem. Biophys., 65, 427 (1956).
Saito, T., Ishihara, Y., Ito, Y., and Fujino, M., Bull. Fac. Fish. Hokkaido Univ., Japan, 7, 159 (1956).
Saito, T., and Ishihara, Y., J. Agric. Chem. Soc., Japan, 30, 426 (1956).
Sanger, F., and Tuppy, H., Biochem. J., 49, 481 (1951).
Sanger, F., and Thompson, E. O. P., Biochem. J., 53, 366 (1953).
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ISHIHARA, Y., SAITO, T., ITO, Y. et al. Structure of Sperm- and Sei-Whale Insulins and their Breakdown by Whale Pepsin. Nature 181, 1468–1469 (1958). https://doi.org/10.1038/1811468b0
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DOI: https://doi.org/10.1038/1811468b0
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