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Isolation of a Heat-resistant Variant of Polio-virus

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Abstract

IT has been shown1 that when preparations of MEF 1 (type II) polio-virus (P. hominis) are exposed to heat at 50° C., there is a marked reduction in the rate of inactivation as the exposure time is increased (see Fig. 1). Bodian et al. 2 have suggested that such a phenomenon occurring during the inactivation of polio-virus with formaldehyde may be due to (1) protection of some virus particles by aggregation, or (2) the presence of inherently resistant particles, and concluded that there was no evidence to support the latter possibility. Since either of these possibilities may explain our results with heat as the inactivating agent, they formed the basis of further experiments.

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References

  1. Stanley, N. F., Dorman, D. C., Ponsford, Joan, and Larkin, Maureen, Aust. J. Exp. Biol. and Med. Sci., Paper IV of series (in the press).

  2. Bodian, D., et al., J. Amer. Med. Assoc., 159, 1444 (1955).

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  3. Stanley, N. F., Dorman, D. C., Ponsford, Joan, and Larkin, Maureen, Aust. J. Exp. Biol. Med. Sci., Paper II of series (in the press).

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Author notes

  1. N. F. STANLEY

    Present address: Department of Microbiology, University of Western Australia, Nedlands, W.A.

  2. D. C. DORMAN

    Present address: Royal Alexandra Hospital for Children, Camperdown, New South Wales

Authors and Affiliations

  1. Institute of Epidemiology and Preventive Medicine, Prince Henry Hospital, Sydney

    N. F. STANLEY, D. C. DORMAN, JOAN PONSFORD & MAUREEN LARKIN

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  1. N. F. STANLEY
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  2. D. C. DORMAN
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  3. JOAN PONSFORD
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  4. MAUREEN LARKIN
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STANLEY, N., DORMAN, D., PONSFORD, J. et al. Isolation of a Heat-resistant Variant of Polio-virus. Nature 178, 413–414 (1956). https://doi.org/10.1038/178413b0

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  • DOI: https://doi.org/10.1038/178413b0

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