Abstract
IT is generally accepted that the effect of clinical doses of reserpine on the circulation is central in origin and that such doses have no peripheral effect of any significance. It has recently been shown that reserpine and serotonin have similar effects on the central nervous system, and that relatively large doses of reserpine in dogs markedly increase the urinary secretion of a metabolite of serotonin1. It has therefore been suggested that certain actions of reserpine are mediated through the liberation of serotonin from the intestine2.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Shore, P. A., Silver, S. L., and Brodie, B. B., Science, 122, 284 (1955).
Pletscher, A., Shore, P. A., and Brodie, B. B., Science, 122, 374 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NAESS, K., SCHANCHE, S. Effect of Reserpine on Serotonin in Rabbit Serum. Nature 177, 1130–1131 (1956). https://doi.org/10.1038/1771130b0
Issue Date:
DOI: https://doi.org/10.1038/1771130b0
- Springer Nature Limited
This article is cited by
-
Bei der anaphylaktischen und allergischen Reaktion freigesetzte Wirkstoffe
Klinische Wochenschrift (1960)
-
Disparition de la 5-hydroxytryptamine dans les granulations des glandes de la peau deDiscoglossus pictus et deRana temporaria après injection de réserpine
Experientia (1958)
-
Reserpine and human platelet 5-hydroxytryptamine
Experientia (1956)