Abstract
LYSINE and glyoxaline-4-5-dicarboxylic acid1 and histidine2 have been shown to activate preparations of Keilin horse-heart succinoxidase in unfavourable environments. A property common to these compounds is their ability to chelate heavy metals. We have accordingly tested the effect of other well-known chelating agents upon this system in bicarbonate buffer, which has been shown by Bonner2 to depress its activity. In Table 1 are shown typical results.
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References
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Keilin, D., and Hartree, E. F., Biochem. J., 44, 205 (1949).
Horecker, B. L., Stotz, E., and Hogness, T. R., J. Biol. Chem., 128, 251 (1939).
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ALTMANN, S., CROOK, E. Activation of Enzymes by Chelating Agents. Nature 171, 76–77 (1953). https://doi.org/10.1038/171076b0
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DOI: https://doi.org/10.1038/171076b0
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