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Production of Anti-Rh in Guinea Pigs from Human Erythrocyte Extracts

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Abstract

IT was noticed by Lubinski and Portnuff1 and others that heat at 50° C. made Rh-positive cells suspended in saline become ‘Rh-negative’. Hubinont2 confirmed this observation and pointed out that Rh-substance could be demonstrated in the supernatant saline by inhibition tests. It seemed that these observations might form the basis of a method for preparing anti-Rh sera in animals, if the extracted material were antigenic.

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References

  1. Lubinski, H. H., and Portnuff, J. C., J. Lab. Clin. Med., 32, 178 (1947).

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  2. Hubinont, P. O., Nature, 161, 642 (1948).

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Authors and Affiliations

  1. Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Maternity Hospital, London, W.6

    JOHN MURRAY & E. C. CLARK

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  1. JOHN MURRAY
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  2. E. C. CLARK
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MURRAY, J., CLARK, E. Production of Anti-Rh in Guinea Pigs from Human Erythrocyte Extracts. Nature 169, 886–887 (1952). https://doi.org/10.1038/169886b0

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