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Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter

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Abstract

Catecholaminergic signaling regulates various physiological functions, such as blood pressure1 and is implicated in drug dependence, affective disorders and male aggressive behavior2,3. The actions of released catecholamines are terminated by sodium-driven, high-affinity transporters in the plasma membrane of the releasing neurons4,5 and by a corticosterone-sensitive, low-affinity, high-capacity extraneuronal transport system6, originally named uptake2, found in sympathetically innervated tissues7 and in central nervous system glia8. Here we report the molecular identification and pharmacological characterization of the extraneuronal catecholamine transporter, which is unrelated to the family of sodium-driven neuronal monoamine transporters5.

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Figure 1: Amino-acid sequence of EMT.
Figure 2: Functional characteristics of EMT.
Figure 3: Tissue distribution and chromosomal localization of EMT.

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Acknowledgements

Our thanks to D. Keppler, J. Babin-Ebell and M. Gliese for tissue samples and to A. Ripperger and B. Wallenwein for technical assistance. This work was supported by grants from the Deutsche Forschungsgemeinschaft (Un34/19-1/B2 and SFB601/A4).

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Authors and Affiliations

  1. Department of Pharmacology, Im Neuenheimer Feld 366 University of Heidelberg, Heidelberg, 69120, Germany

    Dirk Gründemann & Edgar Schömig

  2. Department of Human Genetics, Im Neuenheimer Feld 328 University of Heidelberg, Heidelberg, 69120, Germany

    Birgit Schechinger & Gudrun Rappold

Authors
  1. Dirk Gründemann
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  2. Birgit Schechinger
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  3. Gudrun Rappold
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  4. Edgar Schömig
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Correspondence to Dirk Gründemann.

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Gründemann, D., Schechinger, B., Rappold, G. et al. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci 1, 349–351 (1998). https://doi.org/10.1038/1557

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