Abstract
PERHAPS it is useful to direct attention to the above subject before confusion gets worse confounded. It was pointed out in 1931 that the use of the terms vitamin B2 and anti-dermatitis (anti-pellagra?) factor interchangeably was already causing difficulties1. The discovery by Kuhn and his co-workers that lactofiavine is able to supplement a vitamin B2-deficient diet for the growth of rats constitutes a great advance, but the anti-dermatitis factor (the so-called Haut-faktor of the Heidelberg workers) does not appear to be identical with it. Again, we have observed2 that concentrates of renoflavine (obtained from ox-kidney extracts) have their growth-promoting effect considerably enhanced by the addition of a relatively heat and alkali-stable substance present in ox-kidney extracts, which is not so well adsorbed by fuller's earth in acid solution as the flavine. The tests were carried out with vitamin B-deficient rats receiving vitamins B1 and B2.
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References
Guha, Brit. Med. J., 2; 53; 1931.
Guha and Biswas, Current Science, 3; 300; 1935. Ber. deutsch. chem. Gesell., in press.
Chick and Copping, Chemistry and Industry, 53; 874; 1934.
Booher, Blodgett and Page, J. Biol. Chem., 107; 599; 1934.
Elvehjem and Koehn, NATURE, 134, Dec. 29, 1934.
Langston and Day, Southern Med. J., 26, 128; 1933.
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GUHA, B. Nomenclature of Vitamin B2. Nature 135, 395–396 (1935). https://doi.org/10.1038/135395b0
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DOI: https://doi.org/10.1038/135395b0
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