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Renal physiology in newborns and old people: Similar characteristics but different mechanisms

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Abstract

Five characteristics of neonate renal physiology, namely glomerular hypofiltration, low renal blood flow and alterations in water, sodium and potassium management, disappear during the first year of life but reoccur during senescence. However, the underlying mechanisms are different during the two periods.

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References

  1. Ferraris J, Vallejo G. Relationship between structure and function in the kidney. In: Ferraris J, Vallejo G, Briones L, eds. Pediatric Nephrology. Buenos Aires: Ideografica, 2003: 20–26.

    Google Scholar 

  2. Ghezzi L, Ferraris J. Acute renal failure in the neonate. In: Ceriani Cernadas J, Mariani G, eds. Proneo. Buenos Aires: Panamericana, 2003: 120–127.

    Google Scholar 

  3. Matos P, Duarte-Silva M, Guignard JP. Creatinine reabsorption by the newborn rabbit kidney. Pediatric Reaserch 1998; 44: 639–641.

    CAS  Google Scholar 

  4. Guignard JP. Renal function in the newborn infant. Pediatric clinics of North America 1982; 29: 777.

    PubMed  CAS  Google Scholar 

  5. Bassani C, Ghezzi L. Tables and formula. In: Ferraris J, Vallejo G, Briones L, eds. Pediatric Nephrology. Buenos Aires: Ideografica, 2003: 719.

    Google Scholar 

  6. Anderson S, Meyer T, Brenner B. Mechanisms of age associated glomerularsclerosis. In: Macias Nuñez JF, Cameron S, eds. Renal Function and Disease in the Elderly. London: Butterworths, 1987: 48.

    Google Scholar 

  7. Musso CG, Fainstein I, Kaplan R, Galinsky, Macías NÚñez JF. The patient with hydro-electrolites and acid-base alterations. In: Macías NÚñez JF, Guillén Llera F, Ribera Casado JM, eds. Geriatrics from the Beginings. Barcelona: Glosa, 2001: 245–246.

    Google Scholar 

  8. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31–41.

    Article  PubMed  CAS  Google Scholar 

  9. Latos D. Hemodialysis in the elderly: vascular access and initiation of renal replacement therapy. Seminars in Dialysis 2002; 15: 92.

    Article  Google Scholar 

  10. Toth-Heyn P, Drukker A, Guignard JP. The stressed neonatal kidney: from pathophysiology to clinical management of neonatal vasomotor nephropathy. Pediatr Nephrol 2000; 14: 227–239.

    Article  PubMed  CAS  Google Scholar 

  11. Musso C, Macias Nuñez J. The old kidney: structure and function. Main nephropathies. In: Salgado A, Guillen F, Ruiperez I, eds. Geriatrics Handbook. Barcelona: Masson, 2002: 405–406.

    Google Scholar 

  12. Avner E, Ellis D, Ichikawa I, Yared A. Homeostasis in normal neonate. In: Ichikawa I, ed. Fluid and Electrolytes Disturbances in Pediatrics. Buenos Aires: Inter-Medica, 1992: 119–131.

    Google Scholar 

  13. McLachlan M. Anatomic structural and vascular changes in the ageing kidney. In: Macias Nuñez JF, Cameron S, eds. Renal Function and Disease in the Elderly. London: Butterworths, 1987: 8–20.

    Google Scholar 

  14. Macias Nuñez JF, Bondia Roman A, Rodriguez Commes JL. Physiology and disorders of water balance and electrolytes in the elderly. In: Macias Nuñez JF, Cameron S, eds. Renal Function and Disease in the Elderly. London: Butterworths, 1987: 82.

    Google Scholar 

  15. Fliser D, Ritz E. Renal haemodynamics in the elderly. Nephrol Dial Transplant 1996; 11: 4–5.

    Google Scholar 

  16. Ramirez J, Ghezzi L. Salt and water balance alterations. In: Ferraris J, Vallejo G, Briones L, eds. Pediatric Nephrology. Buenos Aires: Ideografica, 2003: 216.

    Google Scholar 

  17. Zelikovic I. Molecular pathophysiology of tubular transport disorder. Pediatr Nephrol 2001; 16: 919–935.

    Article  PubMed  CAS  Google Scholar 

  18. Igelfinger J. Blood pressure regulation. In: Ichikawa I, ed. Fluid and Electrolytes Disturbances in Pediatrics. Buenos Aires: Inter-Medica, 1992: 67.

    Google Scholar 

  19. Satlin L, Schwartz G. Potassium metabolism. In: Ichikawa I, ed. Fluid and Electrolytes Disturbances in Pediatrics. Buenos Aires: Inter-Medica, 1992: 106–107.

    Google Scholar 

  20. Macias Nuñez JF, Bondia Roman A, Rodriguez Commes JL. Physiology and disorders of watwr balance and electrolytes in the elderly. In: Macias Nuñez JF, Cameron S, eds. Renal Function and Disease in the Elderly. London: Butterworths, 1987: 75–79.

    Google Scholar 

  21. Gallini F, Maggio L, Romagnoli C et al. Progression of renal function in preterm neonates with gestational age equal or less than 32 weeks. Pediatric Nephrol 2000; 15: 119–124.

    Article  CAS  Google Scholar 

  22. Musso CG, Fainstein I, Kaplan R, Galinsky, Macías NÚñez JF. The patient with hydro-electrolites and acid-base alterations. In: Macías NÚñez JF, Guillén Llera F, Ribera Casado JM, eds. Geriatrics from the Beginings. Barcelona: Glosa, 2001: 248.

    Google Scholar 

  23. De Toro Casado R, Macias-Nuñez JF. Physiological characteristics of the renal ageing: clinical consequences. Anales de Medicina Interna 1995; 12: 157–159.

    PubMed  CAS  Google Scholar 

  24. Drukker A, Gugnard JP. Renal aspects of the term and preterm infant: a selective update. Current Opinion in Pediatrics 2002; 14: 175–182.

    Article  PubMed  Google Scholar 

  25. Musso C, Enz P. Farmacokinetics in the elderly. Rev Arg Farmacologia Clinica 1996; 3: 101–105.

    Google Scholar 

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Authors and Affiliations

  1. Department of Adult Nephrology, Hospital Italiano de Buenos Aires, Argentina

    Carlos G. Musso

  2. Department of Pediatric Nephrology, Hospital Italiano de Buenos Aires, Argentina

    Lidia Ghezzi & Jorge Ferraris

Authors
  1. Carlos G. Musso
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  2. Lidia Ghezzi
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  3. Jorge Ferraris
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Musso, C.G., Ghezzi, L. & Ferraris, J. Renal physiology in newborns and old people: Similar characteristics but different mechanisms. Int Urol Nephrol 36, 273–275 (2004). https://doi.org/10.1023/B:UROL.0000034681.60457.84

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  • DOI: https://doi.org/10.1023/B:UROL.0000034681.60457.84

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