Abstract
RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.
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Whitelaw, C., Hiripi, L., Farini, E. et al. On the Use of Post-Transcriptional Processing Elements in Transgenes. Transgenic Res 13, 75–79 (2004). https://doi.org/10.1023/B:TRAG.0000017178.79427.2c
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DOI: https://doi.org/10.1023/B:TRAG.0000017178.79427.2c