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Synthesis of 7-Alkyl(aryl)-6-alkoxycarbonyl-5-fluoroalkyl-1,2,4-tri(tetr)azolo[1,5-a]pyrimidines

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Abstract

Fluorinated 3-oxo esters react with aldehydes and 3-amino-1,2,4-triazoles and 5-aminotetrazoles to give, respectively, 7-alkyl(aryl)-6-alkoxycarbonyl-5-fluoroalkyl-1,2,4-triazolo[1,5-a]pyrimidines and -tetra-zolo[1,5-a]pyrimidines. The same heterocyclic products can be obtained by reaction of 2-benzylidene-2-fluoroacyl esters with the corresponding aminoazoles.

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Authors and Affiliations

  1. Postovskii Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620219 Russia

    M. V. Pryadeina, Ya. V. Burgart, V. I. Saloutin, M. I. Kodess, E. N. Ulomskii & V. L. Rusinov

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  1. M. V. Pryadeina
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  2. Ya. V. Burgart
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  3. V. I. Saloutin
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  4. M. I. Kodess
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  5. E. N. Ulomskii
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  6. V. L. Rusinov
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Pryadeina, M.V., Burgart, Y.V., Saloutin, V.I. et al. Synthesis of 7-Alkyl(aryl)-6-alkoxycarbonyl-5-fluoroalkyl-1,2,4-tri(tetr)azolo[1,5-a]pyrimidines. Russian Journal of Organic Chemistry 40, 902–907 (2004). https://doi.org/10.1023/B:RUJO.0000044558.47152.65

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  • DOI: https://doi.org/10.1023/B:RUJO.0000044558.47152.65

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