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Synthesis of Trifluoroalkyl- and Fluoroaryl-Substituted 4,5-Dihydro-1H-1,2,4-triazole-5-thiones

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Abstract

Reactions of 4-(4-fluorophenyl)-, 4-(4-trifluoromethoxyphenyl)-, 4-(3,4-difluorophenyl)-, 4-(4-trifluoromethylphenyl)-, 4-piperidino-, and 4-(3-pyridyl)thiosemicarbazides with esters gave the corresponding 3,4-disubstituted 4,5-dihydro-1H-1,2,4-triazole-5-thiones and their S-alkyl derivatives. Analogous reactions with methyl 2,2,3,3,4,4,5,5-octafluoropentanoate and 2,2,3,3,4,4,5,5-octafluoropentanenitrile afforded, respectively, the acylation and addition products.

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Authors and Affiliations

  1. Postovskii Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, ul. S. Kovalevskoi 20, Yekaterinburg, 620219, Russia

    E. B. Vasil’eva, D. V. Sevenard, O. G. Khomutov & O. A. Kuznetsova

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  1. E. B. Vasil’eva
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  2. D. V. Sevenard
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  3. O. G. Khomutov
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  4. O. A. Kuznetsova
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Vasil’eva, E.B., Sevenard, D.V., Khomutov, O.G. et al. Synthesis of Trifluoroalkyl- and Fluoroaryl-Substituted 4,5-Dihydro-1H-1,2,4-triazole-5-thiones. Russian Journal of Organic Chemistry 40, 874–878 (2004). https://doi.org/10.1023/B:RUJO.0000044552.07729.40

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  • DOI: https://doi.org/10.1023/B:RUJO.0000044552.07729.40

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