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Heterocyclic Syntheses on the Basis of Arylation Products of Unsaturated Compounds: X. 3-Aryl-2-chloropropanals as Reagents for the Synthesis of 2-Amino-1,3-thiazole Derivatives

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Abstract

Meerwein reaction of arenediazonium chlorides with acrolein gave 3-aryl-2-chloropropanals which were brought into cyclocondensation with thiourea. The resulting 2-amino-5-benzyl-1,3-thiazoles were acylated with carboxylic acid chlorides and phthalic anhydride to afford, respectively, 2-acylamino-5-benzyl-1,3-thiazoles and N-(5-benzyl-1,3-thiazol-2-yl)phthalimides.

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Authors and Affiliations

  1. Ivan Franko Lviv National University, ul. Kirilla i Mefodiya 6, Lviv, 79005, Ukraine

    N. D. Obushak, V. S. Matiichuk, R. Ya. Vasylyshin & Yu. V. Ostapyuk

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  1. N. D. Obushak
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  2. V. S. Matiichuk
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  3. R. Ya. Vasylyshin
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  4. Yu. V. Ostapyuk
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Obushak, N.D., Matiichuk, V.S., Vasylyshin, R.Y. et al. Heterocyclic Syntheses on the Basis of Arylation Products of Unsaturated Compounds: X. 3-Aryl-2-chloropropanals as Reagents for the Synthesis of 2-Amino-1,3-thiazole Derivatives. Russian Journal of Organic Chemistry 40, 383–389 (2004). https://doi.org/10.1023/B:RUJO.0000034976.75646.85

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  • DOI: https://doi.org/10.1023/B:RUJO.0000034976.75646.85

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