Skip to main content
Log in

Effects of N-Arachidonoyl Dopamine, Haloperidol, and Their Mixtures on Regeneration of Freshwater Hydra attenuata

  • Published:
Russian Journal of Developmental Biology Aims and scope Submit manuscript

Abstract

N-Arachidonoyl dopamine and haloperidol, both separately and in different combinations, inhibit regeneration of the gastral and basal regions of hydra. In addition, both substances induce stable anomalies of morphogenesis in the form of outgrowths and additional tentacles in gastral regenerates. In the presence of both substances at different combinations, anomalies either do not appear altogether, or exist for a short time, thus suggesting the normalization pf morphogenesis. Possible mechanisms underlying the effects of these substances are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  • Bezuglov, V.V., Manevich, E.M., Archakov, A.V., et al., Arti-ficially Functioinalized Polyene Fatty Acids Are New Lipid Bioregulators, Bioorg. Khim., 1997, vol. 23, pp. 211–220.

  • Bode, H.R., Head Regeneration in Hydra, Devel. Dyn., 2003, vol. 226, no. 2, pp. 225–236.

    Google Scholar 

  • Buznikov, G.A., Neurotransmitters in Embryogenesis, Chur: Harwood Academic, 1990.

  • Buznikov, G.A. and Bezuglov, V.V., 5-Hydroxytriptamides and 3-Hydroxytiramides of Polyene Fatty Acids in Studies of Prenervous Functions of Biogenic Monoamines, Ros. Fiziol. Zh., 2000, vol. 86, no. 9, pp. 1093–1108.

    Google Scholar 

  • Buznikov, G.A., Lambert, H.W., and Lauder, J.M., Serotonin and Serotonin-Like Substances As Regulators of Early Embryogenesis and Morphogenesis, Cell Tissue Res., 2001, vol. 305, no. 2, pp. 177–186.

    PubMed  Google Scholar 

  • Calberg, M., Localization of Dopamine in the Freshwater Hydrozoan Hydra attenuate, Cell Tissue Res., 1992, vol. 270, pp. 601–607.

    Google Scholar 

  • Fujisawa, T., Hydra Regeneration and Epitheliopeptides, Devel. Dyn., 2003, vol. 226, no. 2, pp. 182–189.

    Google Scholar 

  • Grimmelikhuijzen, C.J.P., Darmer, D., Schmutzler, C., et al., The Peptidergic Nervous System of Coelenterates, Prog. Brain Res., 1992, vol. 92, pp. 137–148.

    PubMed  Google Scholar 

  • Hirose, M., Mochizuki, K., Nishimiya-Fujisawa, C., et al., Evolution of Nervous System Viewed from Cholinergic Sys-tem in Hydra, Intern. Workshop "Hydra and the Evolution of Signalling Pathways, Tutzing, Germany, 2003, p. 43.

    Google Scholar 

  • Holstein, T.W., Hobmayer, E., and Technau, U., Cnidarians: An Evolutionarily Conserved Model System for Regenera-tion? Devel. Dyn., 2003, vol. 226, no. 2, pp. 257–267.

    Google Scholar 

  • Huang, S.M., Bisogno, T., Trevisani, M., et al., An Endoge-nous Capsaicin Substance with High Potency at Recombi-nant and Native Vanilloi Receptor, Proc. Natl. Acad. Sci. USA, 2002, vol. 99, pp. 8400–8408.

    PubMed  Google Scholar 

  • Koizumi, O., Heimfeld, S., and Rode, H.R., Plasticity in the Nervous System of Adult Hydra. 2. Conversion of Ganglion Cells of the Body Column into Epidermal Sensory Cells of the Hypostome, Devel. Biol., 1988, vol. 129, pp. 359–371.

    Google Scholar 

  • Lenhoff, N.M., Water, Culture Solutions, and Buffers, Hydra Research Methods, Lenhoff, O.O., <nt>Ed.</nt>, New York: Plenum, 1982, pp. 19–28.

    Google Scholar 

  • Lentz, T.L., Russel, J., and Barnett, R.C., The Role of the Nervous System in Regeneration of Hydra. The Effect of Neuropharmacological Agent, J. Exp. Zool., 1963, vol. 154, pp. 305–327.

    PubMed  Google Scholar 

  • Markova, L.N. and Ostroumova, T.V., Biogenic Monoamines in Hydra attenuate, Zh. Evol. Biokhim. Fiziol., 1995, vol. 31, no. 2, pp. 141–146.

    Google Scholar 

  • Markova, L.N., Sakharova, N.Yu., and Bezuglov, V.V., Effects of Inhibitors Catecholamine and Spiperone Synthesis On Embryos of Mice and Sea Urchins, Ontogenez, 2000, vol. 31, no. 1, pp. 32–39.

    PubMed  Google Scholar 

  • McCauley, D.W., Serotonin Plays an Early Role in Metamor-phosis of the Hydrozoan Phialidium gregarium, Devel. Biol., 1997, vol. 190, no. 2, pp. 229–240.

    Google Scholar 

  • Muller, W.A., Leitz, T., Stephan, M., et al., Arachidonic Acid and the Control of Body Pattern in Hydra, Roux Arch. Devel. Biol., 1993, vol. 202, pp. 70–76.

    Google Scholar 

  • Ostroumova, T.V. and Markova, L.N., Effects of Inhibitors of Synthesis and Anatgonists of Dopamine on Regenration of Hydra attenuate, Ros. Fiziol. Zh., 2000, vol. 86, no. 10, pp.1246–1253.

    Google Scholar 

  • Rybakin, V.S., Morphogenesis and Pattern Formation in Hydra. 1. Distribution of Morphogenetic Potential, Tsi-tologiya, 2000, vol. 42, no. 10, pp. 937–943.

    Google Scholar 

  • Rybakin, V.S., Morphogenesis and Pattern Formation in Hydra. 2. Molekular Mechanisms, Tsitologiya, 2001, vol. 43, no. 1, pp. 39–45.

    Google Scholar 

  • Shaller, H.C., Hermans-Borgmeyer, J.R.M., and Hoffmeis-ter, S.A.H., Neuronal Control of Development in Hydra, Int. J. Devel. Biol., 1996, vol. 40, pp. 334–339.

    Google Scholar 

  • Venturini, G., Silei, O., Palladini, G., et al., Aminergic Neu-rotransmitters and Adenylate Cyclase in Hydra, Comp. Bio-chem. Physiol., 1984, vol. 78, no. 2, pp. 345–348.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Markova, L.N., Ostroumova, T.V., Bezuglov, V.V. et al. Effects of N-Arachidonoyl Dopamine, Haloperidol, and Their Mixtures on Regeneration of Freshwater Hydra attenuata . Russian Journal of Developmental Biology 35, 298–304 (2004). https://doi.org/10.1023/B:RUDO.0000043824.95991.a4

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:RUDO.0000043824.95991.a4

Navigation