Abstract
Readily accessible N-acetylneuraminic acid (Neu5Ac) glycosyl chloride, which was regarded to be a poor glycosyl donor, was shown to react with dibenzyl phosphoric acid salts in the absence of glycosylation promoters to give the corresponding β-Neu5Ac dibenzyl glycosyl phosphate in high yield.
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Shpirt, A.M., Kononov, L.O., Torgov, V.I. et al. Conversion of N-acetylneuraminic acid glycosyl chloride into dibenzyl glycosyl phosphate: O-glycosylation in the absence of a promoter. Russian Chemical Bulletin 53, 717–719 (2004). https://doi.org/10.1023/B:RUCB.0000035663.15439.84
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DOI: https://doi.org/10.1023/B:RUCB.0000035663.15439.84