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The Potential of Raman Spectroscopy as a Process Analytical Technique During Formulations of Topical Gels and Emulsions

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Abstract

Purpose. The primary objective of this study is to investigate the possibility of using Raman spectroscopy as a process analytical technique (PAT) for quality control during manufacturing of topical dosage forms.

Methods. A fiber-optic Raman probe was used to monitor the formulation of pharmaceutical gel and emulsion in laboratory scale. Raman shifts of typical commercial raw materials used in topical dosage forms were measured to ascertain the potential of this technique for monitoring and analyzing topical products. Spectra of some well-characterized topical gels manufactured in our laboratory were also measured.

Results. Commercial raw materials were found to be Raman sensitive. Due to the difference in chemical composition, raw materials exhibit characteristic peaks that can be exploited to monitor formulation processes. Spectra taken during formulation of an emulsion using Carbopol Ultrez as thickener and Tefose as emulsifying agent show changes in Raman shifts immediately after major formulation steps.

Conclusions. The findings from this work suggest that Raman spectroscopy can be a valuable process analytical technique for quality control of topical gel and cream formulations.

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REFEERENCES

  1. J. K. Gillie, J. Hochlowski, and G. A. Arbuckle-Keil. Infrared spectroscopy, Anal. Chem. Fundamental Reviews.2:71R–79R (2000).

    Google Scholar 

  2. L. A. Kanis, F. C. Viel, J. S. Crespo, J. R. Bertolino, A. T. N. Pires, and V. Soldi. Study of poly(ethylene oxide)/Carbopol blends through thermal analysis and infrared spectroscopy. Polym. 1:3303–3309 (2000).

    Google Scholar 

  3. M. S. Kemper, E. J. Magnuson, S. R. Lowry, W. J. McCarthy, N. Aksornkoae, D. C. Watts, J. R. Johnson, and A. J. Shukla. Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent pharmaceutical topical gel. AAPS J. 3: article 23 (2001).

    Google Scholar 

  4. R. L. Mccreery, A. J. Horn, J. Spencer, and E. Jefferson. Non-invasive identification of materials inside USP vials with Raman spectroscopy and a Raman spectral library. J. Pharm. Sci. 7:1–8 (1998).

    Google Scholar 

  5. C. W. Schmidt. Pharma down PAT-an FDA initiative promot-ing continuous of the drug manufacturing pipeline to be gaining momentum. Mod. Drug Discovery 6:37–42 (2003).

    Google Scholar 

  6. S. K. Freeman. Applications of Laser Raman Spectroscopy.Wiley, New York (1974).

    Google Scholar 

  7. J. G. Grasselli and B. S. Bulkin. Analytical Raman Spectroscopy,Wiley, New York, 1991.

    Google Scholar 

  8. J. J. Laserna (Ed.). Modern Techniques in Raman Spectroscopy, Wiley, New York, 1996.

    Google Scholar 

  9. D. Filmore. Near-IR spectroscopy is helping pharma move to on-line monitoring of dosage unit production. Mod. Drug Dis-covery 6:35–40 (2003).

    Google Scholar 

  10. J. Dong, Y. Ozaki, and K. Nakashima. Infrared, Raman, and near-infrared spectroscopic evidence for the coexistence of vari-ous hydrogen-bond forms in poly(acrylic acid). Macromolecules 0:1111–1117 (1997).

    Google Scholar 

  11. D. Lin-Vien, N. B. Colthup, W. B. Fateley, and J. B. Grasselli. The Handbook of Infrared and Raman Characteristic Frequencies of Organic Molecules.Academic Press, Boston (1991).

    Google Scholar 

  12. B. Schrader. Raman/ Infrared Atlas of Organic Compounds,2nd ed. VCH-Verl.-Ges., Weinkeim (1989).

    Google Scholar 

  13. B. F. Goodrich. Polymers for Pharmaceutical Applications I. General Overview, B. F. Goodrich, 1997.

  14. D. Ostrovskii, P. Jacobsson, B. Nystrom, O. Marstokk, and H. B. M. Kopperud. Raman spectroscopic characterization of association and thermoreversible gelation in aqueous systems of poly(N-acetamidoacrylamide). Macromolecules 2:5552–5560 (1999).

    Google Scholar 

  15. M. K. Gupta and R. Bansil. Raman-spectroscopic and thermal studies of polyacrylamide gels with varying monomer comono-mer ratios. J. Polym. Sci. C-Polym. Lett. 1:969–977 (1983).

    Google Scholar 

  16. M. T. Islam, N. Rodríguez-Hornedo, S. Ciotti, and C. Acker-mann. Fourier transform infrared spectroscopy (FTIR) for the analysis of neutralizer-carbomer and surfactant-carbomer inter-actions in aqueous, hydroalcoholic and anhydrous gel formula-tions. Accepted for publication, AAPS J.(2004).

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109, USA

    Mohammad T. Islam, Na#x00ED;r Rodr#x00ED;guez-Hornedo & Chrisita Ackermann

  2. Pfizer, Inc., Ann Arbor, Michigan, 48105, USA

    Susan Ciotti

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  1. Mohammad T. Islam
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  2. Na#x00ED;r Rodr#x00ED;guez-Hornedo
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  3. Susan Ciotti
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  4. Chrisita Ackermann
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Islam, M.T., Rodr#x00ED;guez-Hornedo, N., Ciotti, S. et al. The Potential of Raman Spectroscopy as a Process Analytical Technique During Formulations of Topical Gels and Emulsions. Pharm Res 21, 1844–1851 (2004). https://doi.org/10.1023/B:PHAM.0000045238.39700.6c

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  • DOI: https://doi.org/10.1023/B:PHAM.0000045238.39700.6c

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