Abstract
We measured the contents of serotonin and histamine in the blood plasma of 62 high-ranking athletes specialized on cyclic sporting disciplines and of 20 generally healthy subjects involved only in amateur sports (a control group). The concentration of serotonin in the blood of the examined sportsmen was, on average, 133% of the respective index in the control group (109 ± 11 ng/ml vs 82 ± 13 ng/ml; P < 0.05). The level of serotonin in the blood plasma demonstrated certain correlations with the dynamics of competition score against the background of similar training loadings, with the heart rate of the tested subjects in the resting state, and with the phase of the training cycle. After a test physical loading (veloergometer test), the level of serotonin dropped somewhat, and such a drop was smaller the better the adaptation to long-term loadings. We discuss the possibility that serotonin present in the circulation can exert a certain influence on the “central” effects of this monoamine (reactions realized by the systems of serotonergic neurons, and neuroendocrine activity of the epiphysis) despite the fact that the blood-brain barrier represents a significant resistivity hindering the diffusion exchange between the pools of this monoamine in the cerebral tissues and blood.
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REFERENCES
Yu. P. Limanskii, “Morphofunctional organization of aminergic systems and their role in the cerebral control of the motor activity,” Usp. Fiziol. Nauk, 21, No. 2, 3–17 (1990).
V.V. Sachenko and V.I. Khorevin, “Serotonin and central mechanisms of motor control, ” Neirofiziologiya/ Neurophysiology, 33, No. 3, 207–224 (2001).
A.M. Koulichenko and V.B. Pavlenko, “Self-initiated behavioral act-related neuronal activity in the region of the raphenuclei of the cat,” Neirofiziologiya/Neurophysiology, 36, No. 1, 57–64 (2004).
A.A. Arinova, “Effect of serotonin on pain sensitivity and nociception-related reactions of the blood pressure,” Éksp. Klin. Farmakol., 57, No. 2, 11–13 (1994).
T.V. Metelitsa, “Serotonin, its physiological and pathophysiologicalroles,” Kardiologiya, 29, No. 2, 120–125 (1989).
H.J. Colebatch, C.R. Olsen, and J.A. Nadel,“Effects of histamine, serotonin and acetylcholine on the peripheral airways, ” J. Appl. Physiol., 21, No. 1, 217–226 (1996).
A.P. Simonenko and V.D. Fedorov, “Serotonin and its receptors in the genesis of stress and adaptation,” Ross. Vestnik Akad. Med. Nauk, No. 8, 9–13 (2002).
W.F. Ganong, Physiology of Humans [in Ukrainian], BaK, L'viv (2002).
Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 6th Edition, G.J. Siegel et al. (eds.), Lippincott-Raven, Philadelphia (1999).
Physiology of Histo-Hematic Barriers (Manual on Physiology)[in Russian ], Nauka, Moscow (1977).
L. Ya. Proshina, “Measurements of histamine and serotonin in one and the same blood sample,” Lab. Delo, No. 3, 90–93 (1981).
B.M. Tward and I.H. Pags, “Serotonin content in some mammalian tissues and a method for its determination,” Am. J. Physiol., 175, No. 1, 157–161 (1954).
A. H. Amin, T.B. Craword, and J. H. Gaddum, “The distribution of 5-hydroxytrypt amine and substance Pin the central nervous system of the dog,” J. Physiol., 126, No. 3, 598–618 (1954).
N.K. Popova, E. V. Naumenko, and V.G. Kolpakov, Serotonin and Behavior [in Russian], Nauka, Novosibirsk (1978).
L.A. Bondarenko, “Physiology of the epiphysis: modern concepts,” Neirofiziologiya/Neurophysiology, 29, No. 3, 212–237 (1997).
E. N. Kryukova, A. V. Karpoushev, S. A. Frolova, and A. N. Fedin, “Effect of histamine on the duration of phases of the respiratory cycle,” Ross. Fiziol. Zh., 87, No. 3, 410–417 (2001).
N. A. Mokhort and N. I. Seredinskaya,“Histamine. Its effects on the heart and vessels, ” Farmakol. Toksikol., 52, No. 6, 95–100 (1989).
G. M. Tolstanova and T.V. Beregova, “Role of H3-histamine receptors in the control of gastric secretion,” Éksp. Klin. Fiziol. Biokhim.,No. 2, 7–11 (2002).
L. O. Cardell and L. Edvinsson, “Characterization of the histamine receptors in the guinea-pig lung:evidence for histamine H3-receptors intrachea,” Br. J. Pharmacol., 111, No. 2, 445–454 (1994).
J. R. Boissier and J. P. Tillemeni, “Diffusion cerebrale des fortes doses d'histaminechez lerat,” J. Pharmacol., 3, 355–356 (1992).
M. L. Vaisfel'd and G. N. Kassil', Histaminein Biochemistry and Physiology [in Russian ], Meditsina, Moscow (1981).
A. A. Spasov and M. V. Chernikov, “Histamine: Its receptors and histaminergic substances,” Khim. Farmakol. Zh., 34, No. 8, 88–95 (2000).
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Dorofeyeva, E.E. Content of Serotonin in the Blood at High Physic Loadings as a Possible Factor Influencing Central Effects of This Monoamine. Neurophysiology 36, 218–222 (2004). https://doi.org/10.1023/B:NEPH.0000048346.22961.45
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DOI: https://doi.org/10.1023/B:NEPH.0000048346.22961.45