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Radiation-induced Tumor after Stereotactic Radiosurgery and Whole Brain Radiotherapy: Case Report and Literature Review

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Abstract

Radiation-induced neoplasms are extremely rare after stereotactic radiosurgery. To date, only 3 cases meet Cahan's criteria in the world literature. We present a fourth case of a radiation-induced neoplasm arising after radiosurgery.

The patient is a 43-year-old woman who presented with a right cerebellar anaplastic astrocytoma 64 months after radiosurgery for metastatic melanoma. Initially, 3 brain metastases involving the inferior right temporal (2 tumors) and right frontal regions were treated. Following radiosurgery, the patient underwent whole brain radiotherapy (37.5 Gy). Twenty-two months later, a second radiosurgical procedure was performed for a recurrent right temporal lobe metastasis. The area of cerebellum where the glioma developed received a maximum dose of 7.7 and 1.5 Gy during the 2 procedures, respectively. Support that radiosurgery contributed to the development of this glioma are the tumor's location and the rarity of adult cerebellar astrocytomas.

The risk of radiation-induced tumors after radiosurgery is unknown. To better define the incidence of radiation-induced neoplasms after radiosurgery, all potential cases should be presented and discussed in an open, candid fashion.

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Authors and Affiliations

  1. Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, MN, USA

    Jon I. McIver & Bruce E. Pollock

  2. The Division of Radiation Oncology, Mayo Clinic and Foundation, Rochester, MN, USA

    Bruce E. Pollock

Authors
  1. Jon I. McIver
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  2. Bruce E. Pollock
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McIver, J.I., Pollock, B.E. Radiation-induced Tumor after Stereotactic Radiosurgery and Whole Brain Radiotherapy: Case Report and Literature Review. J Neurooncol 66, 301–305 (2004). https://doi.org/10.1023/B:NEON.0000014497.28981.4b

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  • DOI: https://doi.org/10.1023/B:NEON.0000014497.28981.4b

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