Abstract
A new efficient synthesis of optically active bicyclic 2-pyridiones has been developed using microwave irradiation. The synthesis is a two-step procedure via Δ2-thiazolines, which only requires a 3 + 2 min reaction time compared to 2 days when using conventional heating. The optimized conditions proved to be suitable for the synthesis of a small library in excellent yields and with limited racemizations.
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Emtenäs, H., Taflin, C. & Almqvist, F. Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via Δ2-thiazolines. Mol Divers 7, 165–169 (2003). https://doi.org/10.1023/B:MODI.0000006800.46154.99
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DOI: https://doi.org/10.1023/B:MODI.0000006800.46154.99