Abstract
An INAA, EDXRF and morphometric study was carried out to determine the zinc content and distribution in 87 prostates of health males aged from 5 days to 87 years. Also, an EDXRF method was used to determine zinc content in prostate fluid samples taken from 22 subjects aged 18 to 75. It was shown that intracellular zinc content increased highly in men over 40 years old. A hypothesis was suggested that excess of intracellular zinc might play an important role at both initiation and promotion stages of prostate carcinogenesis.
Similar content being viewed by others
References
J. M. Fitzpatrick, The Prostate, Churchill Livingstone, Edinburgh, London, Melbourne, New York, 1989.
S. R. Denmeade, J. T. Isaacs, Br. J. Urol., 79 (1997) 2.
D. G. Zaridze, in: European School of Oncology, Prostate Cancer, N. Blokhin Cancer Research Centre, Moscow, 1997, p. 1.
G. Bertrand, R. Vladesco, CR Acad. Sci. (Paris), 173 (1921) 176.
V. Zaichick, T. Sviridova, S. Zaichick, Intern. Urol. Nephrol., 29 (1997) 565.
W. K. Kerr, A. G. Keresteci, H. Mayon, Cancer, 13 (1960) 550.
F. GyÖrkey, K. W. Min, J. A. Huff, P. GyÖrkey, Cancer Res., 27 (1967) 1348.
L. E. Tisell, B. Fjelkegard, K. H. Leissner, J. Urol., 128 (1982) 403.
M. Arnold, D. Sasse, Cancer Res., 21 (1961) 761.
N. K. Dhar, T. C. Goel, P. C. Dube, A. R. Chowdhury, A. B. Kar, Exper. Mol. Pathol., 19 (1973) 139.
A. Leake, G. D. Chisholm, F. K. Habib, Prostate, 4 (1983) 421.
A. Leake, G. D. Chisholm, A. Busuttil, F. K. Habib, Acta Endocrinol., 105 (1984) 281.
A. Feustel, R. Wennrich, Urol. Res., 12 (1984) 147.
K. E. Tvedt, G. Kopstad, O. A. Haugen, J. Halgnuset, Cancer Res., 47 (1987) 323.
F. GyÖrkey, in: Methods in Cancer Research, H. BUSCH (Ed.), Vol. 10, Academic Press, New York, 1973, p. 279.
A. V. Chaklin, S. V. Plotnikov, Urologia i Nefrologia, 4 (1984) 46.
W. F. Whitmore Jr., Cancer, 16 (1963) 1119.
M. B. Garnic, Sci. Amer., 4 (1994) 52.
R. W. Strahan, J. Urol. (Baltimore), 89 (1963) 875.
J. E. Mcneal, E. A. Redwine, F. S. Freiha, T. A. Stamey, Amer. J. Surg. Pathol., 12 (1988) 897.
L. M. Schuman, J. S. Mandel, Prev. Med., 9 (1980) 630.
J. H. Weisburger, B. S. Reddy, P. Hill, L. A. Cohen, E. L. Wynder, N. E. Spingarn, Bull. N.Y. Acad. Med., 56 (1980) 673.
C. Mettlin, Prev. Med., 9 (1980) 601.
D. A. Snowden, R. L. Phillips, W. Choi, Amer. J. Epidemiol., 120 (1984) 244.
R. Talamini, C. La Vecchia, A. De Carli, Br. J. Cancer, 53 (1986) 817.
P. Boyle, D. G. Zaridze, Eur. J. Cancer, 29A (1993) 1048.
E. G. Peeters, Experiantia, 43 (1987) 74.
G. Deplazes, S. P. Hauser, Schweiz. Rundsch. med. Prax., 79 (1990) 464.
L. C. Clark, G. F. Combs, B. W. Turnbull, E. H. Slate, D. K. Chalker, J. Chow, L. S. Davis, R. A. Glover, G. F. Graham, E. G. Gross, A. Krongrad, J. L. Lesher, H. K. Park, B. B. Sanders, C. L. Smith, J. R. Taylor, J. Amer. Med. Assoc., 276 (1996) 1957.
L. C. Clark, B. Dalkin, A. Krongrad, G. F. Combs, B. W. Turnbull, E. H. Slate, R. Witherington, J. H. Herlong, E. Janosko, D. Carpenter, C. Borosso, S. Falk, J. Rounder, Br. J. Urol., 81 (1998) 730.
I. D. Rotkin, in: Prostate Cancer, D. Coffey, J. Isaacs (Eds), Geneva, 1979, p. 56.
J. P. Kavanagh, J. Reprod. Fertil., 75 (1985) 35.
V. Zaichick, Fresenius J. Anal. Chem., 352 (1995) 219.
R. Parr, Intercomparison of Minor and Trace Elements in IAEA Animal Muscle (H-4), Report No 2, IAEA, Vienna, 1980.
A. Korelo, V. Zaichick, in:Activation Analysis in Environmental Protection, Join Institute of Nuclear Research, Dubna, 1993, p. 326.
E. G. Zezerov, E. S. Severin, Clin. Lab. Diagnostika, 5 (1997) 32.
K. H. Leissner, B. Fjelkegard, L. E. Tisell, Invest. Urol., 18 (1980) 32.
G. V. Iyengar, W. E. Kollmer, H. J. M. Bowen, The Elemental Composition of Human Tissues and Body Fluids, Verlag Chemie, Weinheim, 1978.
S. M. Boyarinova, in: Zinc, Copper, Manganese, and Cobalt as Bioelements, Issue V, Ivano-Frankovsk, 1962, p. 127.
E. Hienzsch, H.-J. Schneider, M. Anke, Z. Urol. Nephrol., 63 (1970) 543.
Report of the Task Group of Reference Man, ICRP No 23, Pergamon Press, Oxford, 1975.
W. R. Fair, J. J. Cordonnier, J. Urol., 120 (1978) 695.
R. Eliasson, C. Lindholmer, G. Leander, Intern. Urol. Nephrol., 2 (1970) 309.
G. Paz, A. Sofer, T. Z. Homonnai, P. F. Kraicer, Intern. J. Fertil., 22 (1977) 140.
D. Canale, M. Bartelloni, A. Negroni, P. Meschini, P. L. Izzo, B. Bianchi, G. F. Menchini-fabris, Intern. J. Androl., 9 (1986) 477.
D. Behne, H. Gessner, G. Wolters, J. Brotherton, Intern. J. Androl., 11 (1988) 415.
A. R. Mackenzie, T. Hall, W. F. Whitmore, Nature, 193 (1962) 72.
R. U. Anderson, W. R. Fair, Invest. Urol., 14 (1976) 137.
W. R. Fair, J. Couch, N. Wehner, Urology, 7 (1976) 169.
Z. T. Homonnai, H. Matzkin, N. Fainman, G. Paz, P. F. Kraicer, Fertil. Steril., 29 (1978) 539.
J. L. Marmar, S. Katz, D. E. Praiss, T. J. De Benedictis, Urology, 16 (1980) 478.
R. Lahtonen, Prostate, 6 (1985) 177.
A. Feustel, R. Wennrich, H. Dittrich, Urol. Res., 15 (1987) 161.
M. B. Sorensen, M. Stoltenberg, S. Juhl, G. Danscher, E. Ernst, Prostate, 31 (1997) 125.
H. K. Schwartz, Cancer Res., 35 (1975) 3481.
R. J. Matusik, C. Kreis, P. Mcnicol, R. Sweetland, C. Mullin, W. H. Fleming, J. G. Dodd, Biochem. Cell Biol., 64 (1986) 601.
L. J. Blok, M. E. Grossmann, J. E. Perry, D. J. Tindall, Mol. Endocrinol., 9 (1995) 1610.
Y. G. Zezerov, Voprosi Onkologii, 47 (2001) 174.
G. N. Schrauzer, D. A. White, C. J. Schneider, Bioinorg. Chem., 7 (1977) 35.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zaichick, V. INAA and EDXRF applications in the age dynamics assessment of Zn content and distribution in the normal human prostate. Journal of Radioanalytical and Nuclear Chemistry 262, 229–234 (2004). https://doi.org/10.1023/B:JRNC.0000040879.45030.4f
Issue Date:
DOI: https://doi.org/10.1023/B:JRNC.0000040879.45030.4f