Summary
The concentration of Zn, Cd and Se in unseparated tissues and epithelial and stromal fractions of normal prostate gland, BPH and prostatic carcinomas of different histological grading were determined by flameless AAS. There were distinct differences in the content of Zn, Cd and Se in the epithelial and stromal fractions depending on histology. In all cases the concentration of these elements in the epithelial fractions was higher than in stromal fractions. These differences are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cowan RA, Cowan SK, Grant JK, Elder HY (1977) Biochemical investigations of separated epithelium and stroma from benign hyperplastic prostatic tissue. J Endocrinol 74:111–120
Dürre P, Andreesen JR (1986) Die biologische Bedeutung von Selen. Biologie in unserer Zeit 16:12–23
Feustel A, Wennrich R, Steiniger D, Klauß P (1982) Zinc and cadmium concentration in prostatic carcinoma of different grading in comparison to normal prostate tissue and adenofibromyomatosis (BPH). Urol Res 10:301
Feustel A, Wennrich R (1984) Zinc and cadmium in cell fractions of prostatic cancer tissue of different histological grading in comparison to BPH and normal prostate. Urol Res 12:147
Feustel A, Wennrich R (1984) Determination of the distribution of zinc and cadmium in cellular fractions of BPH, normal prostate and prostatic cancer of different histology by atomic and laser absorption spectrometry in tissue slices. Urol Res 12:253–256
Feustel A, Wennrich R, Vorberg B (1986) Schwermetallgehalte in Zellfrationen menschlicher Harnblasentumoren und normaler Harnblase. 8th Symp Exp Urol Mainz, July 1986
Habib FK, Mason MK, Smith PH, Stitch SR (1979) Cancer of the prostate: early diagnosis by zinc and hormone analysis. Br J Cancer 39:700–704
Habib FK, Tesdale AL, Chisholm GD, Busuttil A (1980) Androgen metabolism in the epithelial and stromal components of the human hyperplastic prostate. J Endocrinol 91:23–32
Habib FK, Leake A, Beynon L, Chisholm GD (1984) Studies on the relationship between zinc and androgens in the human prostate. Adv Urol Oncol Endocrinol, Rome, pp 143–150
Hoffmann L, Putzke HP, Kampehl HJ, Russbult R, Gase P, Simon C, Erdmann T, Huckstorf C (1985) Carcinogenic effects of cadmium on the prostate of the rat. J Cancer Res Clin Oncol 109:193–199
Lathonen R (1985) Zinc and cadmium concentrations in whole tissue and in separated epithelium and stroma from human benign prostatic hyperplastic glands. Prostate 6:177–183
McLoughlin MG, Bruchowsky N (1983) Stromal — epithelial interaction. In: Hinman F Jr (ed) Benign prostatic hypertrophy. Springer, New York
Piscator M (1981) Role of cadmium in carcinogenesis with special reference to cancer of the prostate. Environ Health Perspect 40:107–120
Salonen JT, Salonen R, Lappeteläinen R, Mäenpää PH, Alfthan G, Puska P (1985) Risk of cancer in relation to serum concentration of selenium and vitamines A and E: matched case control analysis of prospective cata. Br Med J 290:417–420
Webber MM (1985) Selenium prevents the growth stimulatory effects of cadmium on human prostatic epithelium. Biochem Biophys Res Commun 127:871–877
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Feustel, A., Wennrich, R. & Dittrich, H. Zinc, cadmium and selenium concentrations in separated epithelium and stroma from prostatic tissues of different histology. Urol. Res. 15, 161–163 (1987). https://doi.org/10.1007/BF00254429
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00254429