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Phosphonate complexes of 99mTc - Potential bone scintigraphy agents

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Abstract

The synthesis of several combined aminophosphonate ligands containing an N-carboxymethyl group is described. The complexes of these ligands were prepared both with 99mTc and 99Tc, and the dependence of their formation on pH and the stoichiometry of reagents was studied. All of the complexes were pharmacologically evaluated. The distribution of radioactivity and bone uptake were determined, and discussed in comparison with clinically used phosphonate complexes.

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Authors and Affiliations

  1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic Flemingovo nám. 2, 166 10, Prague, Czech Republic

    J. Doubský

  2. Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University Hlavova 2030, 128 40, Prague, Czech Republic

    L. Lešetický

  3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University Heyrovského 1203, 500 05, Hradec Králové, Czech Republic

    M. Lázníček & A. Lázníčková

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  1. J. Doubský
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  2. M. Lázníček
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  3. A. Lázníčková
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  4. L. Lešetický
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Doubský, J., Lázníček, M., Lázníčková, A. et al. Phosphonate complexes of 99mTc - Potential bone scintigraphy agents. Journal of Radioanalytical and Nuclear Chemistry 260, 53–59 (2004). https://doi.org/10.1023/B:JRNC.0000027061.68181.fa

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  • DOI: https://doi.org/10.1023/B:JRNC.0000027061.68181.fa

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