Abstract
The adsorption of pyrazinamide (PZA) and 4-aminopyrimidine (4APM) on natural sepiolite, loughlinite (Na-sepiolite), natural and ion-exchanged montmorillonite (Co- or Cu-montmorillonite) has been investigated using FT-IR spectroscopy. The intercalation of pyrazinamide and 4-aminopyrimidine within natural and ion-exchanged montmorillonites has been shown by X-ray diffraction to increase the interlayer spacing. PZA and 4APM interacted with montmorillonites by direct or indirect coordination (through water molecules) to the exchangeable cations. The spectroscopic results indicate that PZA or 4APM molecules adsorbed on sepiolite and loughlinite are coordinated to Lewis acidic centers or surface hydroxyls by H-bonding interaction through either one of the pyrimidine ring nitrogen lone pairs (in the case of 4APM) or carbonyl group (in the case of PZA).
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References
J.J. Fahey, M. Ross, and J.M. Axelrod: Am. Miner. 45, 270 (1960).
S. Kadir, H. Bas, and Z. Karakas: Can. Miner. 40, 1091 (2002).
K.A. Brauner and Preisinger: Tschermaks Mineral. Petrogr. Mitt. 6, 120 (1956).
J.M. Serratosa: in M.M. Mortland and V.C. Farmer (eds.), International Clay Conference, 1978, Elsevier Science, Amsterdam (1979) pp. 99-109.
B.K.G. Theng: The Chemistry of Clay Organic Reactions, Hilger, London (1974).
J.M. Thomas and C.R. Theocharis: in J.L. Atwood, J.E.D. Davies, and D.D. MacNicol (eds.), Inclusion Compounds, Vol. 5, Oxford University Press, New York (1991), pp. 104-135.
S. Akyuz, T. Akyuz, and J.E.D. Davies: J. Incl. Phenom. 15, 105 (1993).
S. Akyuz, T. Akyuz, and J.E.D. Davies: J. Incl. Phenom. 18, 123-135 (1994).
B.G. Katzung: Basic and Clinical Pharmacology, Prentice-Hall, London (1989) 582 pp.
V. Opletalova, J. Hartl, A. Patel, K. Palat, and V. Buchta: Farmaco 57, 135 (2002).
R.K. Murray, D.K. Granner, P.A. Mayes, and V.W. Rodwell: Harper's Biochemistry, 22nd edn., Prentice Hall, London (1990), 332 pp.
S.N. Pandeya, D. Sriram, G. Nath, and E. de Clercq: Farmaco 54, 624 (1999).
S. Barbu, I. Grecu, and L. Ghizdavu: Inorg. Chim. Acta 40, X78 (1980).
S. Akyuz, T. Akyuz, and J.E.D. Davies: J. Struct. Chem. 40(5), 796 (1999a).
S. Akyuz, T. Akyuz, and J.E.D. Davies: J. Mol. Struct. 482-483, 49 (1999b).
S. Akyuz, T. Akyuz, and J.E.D. Davies: Vibrat. Spectrosc. 22, 11 (2000).
S. Akyuz, T. Akyuz, and A.E. Yakar: J. Mol. Struct. 565-566, 487 (2001).
S. Akyuz and T. Akyuz: J. Mol. Struct. 651-653, 205 (2002a).
S. Akyuz and T. Akyuz: J. Incl. Phenom. (in press) (2002b).
M. Ogawa, T. Hashizume, K. Kuroda, and C. Kato: Inorg. Chem. 30, 584 (1991).
N. Khaorapapong, K. Kuroda, T. Hashizume, M. Ogawa, and C. Kato: Appl. Clay Sci. 19, 69 (2001).
E. Akalin and S. Akyuz: J. Mol. Struct. 482, 175 (1999).
A.K. Kalkar, N.M. Bhosekar, and S.T. Kshirsagar: Spectrochim. Acta 45A, 635 (1989).
R. Rytwo, D. Tropp, and C. Serban: Appl. Clay Sci. 20, 273 (2002).
S. Akyuz: J. Mol. Struct. 651-653, 541 (2002c).
R.L. Frost, O.B. Locos, H. Ruan, and J.T. Kloprogge: Vibrational Spectroscopy. 27, 1 (2001).
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Akyuz, S., Akyuz, T. FT-IR Spectroscopic Investigations Adsorption of Pyrazinamide and 4-Aminopyrimidine by Clays. Journal of Inclusion Phenomena 48, 75–80 (2004). https://doi.org/10.1023/B:JIPH.0000016587.89549.0e
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DOI: https://doi.org/10.1023/B:JIPH.0000016587.89549.0e