Abstract
A common 870G > A polymorphism in the gene for cyclin D1, CCND1, has been linked to alternative splicing and cancer susceptibility. To analyze its role for breast cancer, we determined the CCND1 genotype in 500 breast cancer patients and 500 controls. CCND1 genotype frequencies were similar among patients and controls. The CCND1 genotype was furthermore not associated with tumor characteristics. We conclude that the CCND1 870G > A polymorphism is not associated with breast cancer.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Sherr CJ: Cancer cell cycles. Science 274: 1672-1677, 1996
Pagano M, Theodoras AM, Tam SW, Draetta GF: Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev 8: 1627-1639, 1994
Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WD, Heighway J: Alternate splicing produces a novel cyclin D1 transcript. Oncogene 11: 1005-1011, 1995
Wang L, Habuchi T, Takahashi T, Mitsumori K, Kamoto T, Kakehi Y, Kakinuma H, Sato K, Nakamura A, Ogawa O, Kato T: Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer. Carcinogenesis 23: 257-264, 2002
Wang L, Habuchi T, Mitsumori K, Li Z, Kamoto T, Kinoshita H, Tsuchiya N, Sato K, Ohyama C, Nakamura A, Ogawa O, Kato T: Increased risk of prostate cancer associated with AA genotype of cyclin D1 gene A870G polymorphism. Int J Cancer 103: 116-120, 2003
Porter TR, Richards FM, Houlston RS, Evans DG, Jankowski JA, Macdonald F, Norbury G, Payne SJ, Fisher SA, Tomlinson I, Maher ER: Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. Oncogene 21: 1928-1933, 2002
Wong YK, Lin SC, Chang CS, Tseng YH, Liu CJ, Lin HC, Chang KW: Cyclin D1 genotype in areca-associated oral squamous cell carcinoma. J Oral Pathol Med 32: 265-270, 2003
Simpson DJ, Fryer AA, Grossman AB, Wass JA, Pfeifer M, Kros JM, Clayton RN, Farrell WE: Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas. Carcinogenesis 22: 1801-1807, 2001
Zheng Y, Shen H, Sturgis EM, Wang LE, Eicher SA, Strom SS, Frazier ML, Spitz MR, Wei Q: Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study. Carcinogenesis 22: 1195-1199, 2001
Matthias C, Branigan K, Jahnke V, Leder K, Haas J, Heighway J, Jones PW, Strange RC, Fryer AA, Hoban PR: Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 4: 2411-2418, 1998
Deng L, Zhao XR, Pan KF, Wang Y, Deng XY, Lu YY, Cao Y: Cyclin D1 polymorphism and the susceptibility to NPC using DHPLC. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34: 16-20, 2002
Cortessis V, Siegmund K, Xue S, Ross RK, Yu MC: A casecontrol study of cyclin D1 CCND1 870A>G polymorphism and bladder cancer. Carcinogenesis (in press)
Xing D, Tan W, Lin D: Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review). Oncol Rep 10: 1615-1623, 2003
Yu C, Lu W, Tan W, Xing D, Liang G, Miao X, Lin D: Lack of association between CCND1 G870A polymorphism and risk of esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 12: 176, 2003
Zhang YJ, Chen SY, Chen CJ, Santella RM: Polymorphisms in cyclin D1 gene and hepatocellular carcinoma. Mol Carcinog 33: 125-129, 2002
McKay JA, Douglas JJ, Ross VG, Curran S, Murray GI, Cassidy J, McLeod HL: Cyclin D1 protein expression and gene polymorphism in colorectal cancer. Aberdeen Colorectal Initiative. Int J Cancer 88: 77-81, 2000
Hosokawa Y, Tu T, Tahara H, Smith AP, Arnold A: Absence of cyclin D1/PRAD1 point mutations in human breast cancers and parathyroid adenomas and identification of a new cyclin D1 gene polymorphism. Cancer Lett 93: 165-170, 1995
Krippl P, Langsenlehner U, Renner W, Yazdani-Biuki B, Wolf G, Wascher TC, Paulweber B, Haas J, Samonigg H: A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk. Int J Cancer 106: 468-471, 2003
Langsenlehner U, Krippl P, Renner W, Yazdani-Biuki B, Wolf G, Wascher TC, Paulweber B, Weitzer W, Samonigg H: The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk. Breast Cancer Res Treat 81: 169-172, 2003
Krippl P, Langsenlehner U, Renner W, Yazdani-Biuki B, Wolf G, Wascher TC, Paulweber B, Bahadori B, Samonigg H: The L10P polymorphism of the transforming growth factor-beta 1 gene is not associated with breast cancer risk. Cancer Lett (in press)
Sawa H, Ohshima TA, Ukita H, Murakami H, Chiba Y, Kamada H, Hara M, Saito I: Alternatively spliced forms of cyclin D1 modulate entry into the cell cycle in an inverse manner. Oncogene 16: 1701-1712, 1998
Holley SL, Parkes G, Matthias C, Bockmuhl U, Jahnke V, Leder K, Strange RC, Fryer AA, Hoban PR: Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck. Am J Pathol 159: 1917-1924, 2001
Howe D, Lynas C: The cyclin D1 alternative transcripts [a] and [b] are expressed in normal and malignant lymphocytes and their relative levels are influenced by the polymorphism at codon 241. Haematologica 86: 563-569, 2001
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Krippl, P., Langsenlehner, U., Renner, W. et al. The 870G>A Polymorphism of the Cyclin D1 Gene is not Associated with Breast Cancer. Breast Cancer Res Treat 82, 165–168 (2003). https://doi.org/10.1023/B:BREA.0000004372.20461.33
Issue Date:
DOI: https://doi.org/10.1023/B:BREA.0000004372.20461.33