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Randomization-Based Hypothesis Testing from Event-Related Data

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Abstract

Methods are described for non-parametric significance testing from event-related encephalographic data, using randomization tests. These methods may be applied in both signal space and source space. The methods include within-subject between-condition comparisons, paired and unpaired comparisons, and within-group and between-group comparisons. Test statistics are also derived for comparing the spatial or temporal response patterns, independent of specific changes at individual locations. Novel methods for testing peak-height significance, and also for making map-wide comparisons, are described. These methods have been validated using simulated data.

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References

  • Altman, D.G. Practical statistics for medical research. Chapman and Hall, London, 1991.

    Google Scholar 

  • Benjamini, Y. and Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J.R. Stat. Soc. B., 1995, 57(1): 289–300.

    Google Scholar 

  • Duffy, F.H., Bartels, P.H. and Burchfiel, J.L. Significance probability mapping: an aid in the topographic analysis of brain electrical activity. EEG Clin. Neurophysiol., 1981, 51: 455–462.

    Google Scholar 

  • Friston, K.J., Holmes, A.P., Worsley, K.J., Poline, J-P., Frith, C.D. and Frackowiak, R.S.J. Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping, 1995, 2: 189–210.

    Google Scholar 

  • Greenblatt, R.E. and Gao, L. M/EEG source space statistical parametric mapping. NeuroImage, 1999, 9: S156.

  • Holmes, A.P., Blair, R.C., Watson, J.D.G. and Ford, I. Non-parametric analysis of statistic images from functional mapping experiments. Journal of Cerebral Blood Flow and Metabolism, 1996, 16: 7–22.

    PubMed  Google Scholar 

  • Karniski, W., Blair, R.C. and Snider, A.D. An exact statistical method for comparing topographic maps, with any number of subjects and electrodes. Brain Topography, 1994, 6(3): 203–210.

    PubMed  Google Scholar 

  • Nichols, T.E. and Holmes, A.P. Nonparametric analysis of PET functional neuroimaging experiments: a primer. Human Brain Mapping, 2001, 15: 1–25.

    Google Scholar 

  • Pascual-Marqui, R.D., Michel, C.M. and Lehmann, D. Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. Intl. J. Psychophysiol., 1994, 18: 49–65.

    Google Scholar 

  • Pflieger, M.E., Simpson, G.V. and Vaughn, H.G. Improved estimation of ERP source activities in the presence of realistic background EEG. Human Brain Mapping, 1995, Suppl. 1: 101.

    Google Scholar 

  • Raz, J., Zheng, H., Ombao, H. and Turetsky, B. Statistical tests for fMRI based on experimental randomization. NeuroImage, 2003, 19: 226–32.

    PubMed  Google Scholar 

  • Schimmel, H. The (±) reference: Accuracy of estimated mean components in average response studies. Science, 1967, 157: 92–94.

    PubMed  Google Scholar 

  • Westfall, P.H. and Young, S.S. Resampling-based multiple testing: examples and methods for p-value adjustment. Wiley, New York, 1993.

    Google Scholar 

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Greenblatt, R.E., Pflieger, M.E. Randomization-Based Hypothesis Testing from Event-Related Data. Brain Topogr 16, 225–232 (2004). https://doi.org/10.1023/B:BRAT.0000032856.48286.18

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  • DOI: https://doi.org/10.1023/B:BRAT.0000032856.48286.18

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