Abstract
The enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester to the optically active (S)-ketoprofen was carried out in a dispersed aqueous lipase reaction system induced by the inclusion of chiral cyclodextrins for complexation of the substrate. Hydroxypropyl-β-cyclodextrin was the most effective chiral selector and disperser giving an enantiomeric excess and conversion yield of 0.99 and 0.49, respectively.
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Kim, SH., Kim, TK., Shin, GS. et al. Enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester in dispersed aqueous reaction system induced by chiral cyclodextrin. Biotechnology Letters 26, 965–969 (2004). https://doi.org/10.1023/B:BILE.0000030040.13828.d7
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DOI: https://doi.org/10.1023/B:BILE.0000030040.13828.d7