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Enantioselective hydrolysis of (R,S)-Naproxen methyl ester using Candida rugosa lipase with calix[4]arene derivatives

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Abstract

Candida rugosa lipase has been immobilized on a variety of calix[4]arene derivatives using the sol–gel encapsulation technique, and the catalytic activities of the resulting encapsulated lipases towards the hydrolysis of p-nitrophenyl palmitate and the hydrolytic kinetic resolution of racemic Naproxen methyl ester were evaluated using standard techniques. The results revealed that the calix[4]arene-based immobilized encapsulated lipases 5-CRL and 6-CRL gave higher levels of enantioselectivity and conversion than the free encapsulated lipase.

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Acknowledgments

We would like to thank The Research Foundation of Selcuk University (BAP) for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Selcuk University, 42075, Konya, Turkey

    Ezgi Akceylan, Enise Akoz, Ozlem Sahin & Mustafa Yilmaz

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  1. Ezgi Akceylan
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  2. Enise Akoz
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  3. Ozlem Sahin
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  4. Mustafa Yilmaz
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Correspondence to Ezgi Akceylan.

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Akceylan, E., Akoz, E., Sahin, O. et al. Enantioselective hydrolysis of (R,S)-Naproxen methyl ester using Candida rugosa lipase with calix[4]arene derivatives. J Incl Phenom Macrocycl Chem 81, 237–243 (2015). https://doi.org/10.1007/s10847-014-0452-0

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