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In Vitro Genotoxic and Cytotoxic Effects of Protein Somatic Products from Helminths on Donor Blood Lymphocytes

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Abstract

Protein somatic products of adult helminths Hymenolepis nana and Toxocara canis and secretory-excretory somatic product of Trichinella spiralis larvae in vitro produced genotoxic and cytotoxic effects on donor blood lymphocytes, which manifested in accumulation of single-chain breaks, alkaline-labile sites in nuclear DNA, and apoptotic cells. This effect depended on the concentration of parasitic protein products during coculturing.

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Authors and Affiliations

  1. Department of Medical Biology and General Genetics, Vitebsk State Medical University, Russia

    Vl. Ya. Bekish & A. D. Durnev

  2. Laboratory for Pharmacology of Mutagenesis, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    Vl. Ya. Bekish & A. D. Durnev

Authors
  1. Vl. Ya. Bekish
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  2. A. D. Durnev
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Bekish, V.Y., Durnev, A.D. In Vitro Genotoxic and Cytotoxic Effects of Protein Somatic Products from Helminths on Donor Blood Lymphocytes. Bulletin of Experimental Biology and Medicine 138, 174–176 (2004). https://doi.org/10.1023/B:BEBM.0000048380.51708.75

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  • DOI: https://doi.org/10.1023/B:BEBM.0000048380.51708.75

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