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Induction of Apoptosis in Bone Marrow Cells is Mediated via Purinergic Receptors

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Abstract

ATP activity in mouse bone marrow cells was in vitro estimated by expression of phosphatidylserine on the outer membrane surface using FITC-labeled annexin. ATP induced apoptosis in bone marrow cells. Purinergic receptor antagonists PPADS and suramin modulated the apoptotic effect of ATP on hemopoietic cells. Acute and subacute administration of doxorubicin, an inductor of oxidative burst, decreased cell sensitivity to ATP and abolished its apoptotic effect.

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Authors and Affiliations

  1. Department for Animal Anatomy and Physiology, Krasnoyarsk State Agrarian University; Department of Biochemistry, Course of Medical Chemistry, Krasnoyarsk State Medical Academy, Russia

    Yu. A. Uspenskaya, S. V. Mikhutkina, E. I. Taksanova, N. N. Popova, R. Ya. Olovyannikova & A. B. Salmina

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  1. Yu. A. Uspenskaya
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  2. S. V. Mikhutkina
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  3. E. I. Taksanova
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  4. N. N. Popova
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  5. R. Ya. Olovyannikova
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  6. A. B. Salmina
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Uspenskaya, Y.A., Mikhutkina, S.V., Taksanova, E.I. et al. Induction of Apoptosis in Bone Marrow Cells is Mediated via Purinergic Receptors. Bulletin of Experimental Biology and Medicine 138, 116–118 (2004). https://doi.org/10.1023/B:BEBM.0000048365.80201.fc

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  • DOI: https://doi.org/10.1023/B:BEBM.0000048365.80201.fc

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