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Expression of Argyrophilic Proteins in the Nucleolar Organizer Regions of Human Thymocytes and Thymic Epitheliocytes under Conditions of Coculturing with Vilon and Epithalon Peptides

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Abstract

Vilon stimulated and Epithalon suppressed the expression of argyrophilic proteins in nucleolar organizer regions of thymocytes and epithelial cells, stimulating or reducing, respectively, the formation, assembly, and transport of ribosomes into the cytoplasm and thus determining the intensity of protein synthesis in these cells. A direct mitogenic effect of Vilon was also revealed: this peptide promoted thymocyte transformation into proliferating blast cells.

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Authors and Affiliations

  1. N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences; Institute of Immunology, Ministry of Health of Russia, Moscow

    N. T. Raikhlin, I. A. Bukaeva, E. A. Smirnova, A. A. Yarilin, N. I. Sharova, M. M. Mitneva, V. Kh. Khavinson, V. O. Polyakova, A. V. Trofimov & I. M. Kvetnoi

  2. St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences, Russia

    N. T. Raikhlin, I. A. Bukaeva, E. A. Smirnova, A. A. Yarilin, N. I. Sharova, M. M. Mitneva, V. Kh. Khavinson, V. O. Polyakova, A. V. Trofimov & I. M. Kvetnoi

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  1. N. T. Raikhlin
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  2. I. A. Bukaeva
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  3. E. A. Smirnova
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  4. A. A. Yarilin
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  5. N. I. Sharova
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  6. M. M. Mitneva
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  7. V. Kh. Khavinson
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  8. V. O. Polyakova
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  9. A. V. Trofimov
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  10. I. M. Kvetnoi
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Raikhlin, N.T., Bukaeva, I.A., Smirnova, E.A. et al. Expression of Argyrophilic Proteins in the Nucleolar Organizer Regions of Human Thymocytes and Thymic Epitheliocytes under Conditions of Coculturing with Vilon and Epithalon Peptides. Bulletin of Experimental Biology and Medicine 137, 588–591 (2004). https://doi.org/10.1023/B:BEBM.0000042720.40439.16

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  • DOI: https://doi.org/10.1023/B:BEBM.0000042720.40439.16

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