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Genotype-Dependent Changes in Pain Thresholds in Adult Mice after Neonatal Treatment

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Abstract

We studied the effect of neonatal treatment with pharmacological preparations (Semax and buspiron) and solvents (distilled water and physiological saline) on the pain threshold in 3-4-month-old mice of 6 genotypes. Neonatal administration of the solvent (nociceptive stimulation) decreased pain thresholds in DBA/2, 101/HY, and RSB males, but not in female mice and animals of other strains. Neonatal administration of Semax significantly increased pain thresholds in adult DBA/2 and 101/HY males compared to those in animals neonatally treated with the solvent. Injection of buspiron in the neonatal period decreased pain thresholds in RLB males.

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Authors and Affiliations

  1. Laboratory for Physiology and Genetics of Behavior, Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov, Moscow State University, Moscow

    O. S. Boyarshinova, O. B. Shilova, N. V. Markina, I. V. Gichenok, O. V. Perepelkina & I. I. Poletaeva

  2. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow

    O. S. Boyarshinova, O. B. Shilova, N. V. Markina, I. V. Gichenok, O. V. Perepelkina & I. I. Poletaeva

Authors
  1. O. S. Boyarshinova
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  2. O. B. Shilova
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  3. N. V. Markina
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  4. I. V. Gichenok
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  5. O. V. Perepelkina
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  6. I. I. Poletaeva
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Boyarshinova, O.S., Shilova, O.B., Markina, N.V. et al. Genotype-Dependent Changes in Pain Thresholds in Adult Mice after Neonatal Treatment. Bulletin of Experimental Biology and Medicine 137, 532–534 (2004). https://doi.org/10.1023/B:BEBM.0000042703.99534.40

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  • DOI: https://doi.org/10.1023/B:BEBM.0000042703.99534.40

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