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Effect of M2 Muscarinic Receptor Blockade in Rats with Haloperidol-Produced Catatonic Syndrome

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Abstract

We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtypes of muscarinic receptors are involved in the regulation of dopamine concentration.

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Authors and Affiliations

  1. Laboratory of Biochemistry, Laboratory of Medicinal Toxicology, Laboratory of Toxicology, Laboratory of Psychopharmacology, Laboratory of Applied Pharmacology, Institute of Toxicology, Russian Ministry of Health, St. Petersburg

    S. G. Dagaev, O. A. Fil'ko, L. G. Kubarskaya, A. V. Khrabrova, L. A. Mukovskii, R. I. Glukhova, V. I. Sanotskii & V. B. Dolgo-Saburov

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  1. S. G. Dagaev
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  2. O. A. Fil'ko
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  3. L. G. Kubarskaya
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  4. A. V. Khrabrova
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  5. L. A. Mukovskii
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  6. R. I. Glukhova
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  7. V. I. Sanotskii
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  8. V. B. Dolgo-Saburov
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Dagaev, S.G., Fil'ko, O.A., Kubarskaya, L.G. et al. Effect of M2 Muscarinic Receptor Blockade in Rats with Haloperidol-Produced Catatonic Syndrome. Bulletin of Experimental Biology and Medicine 137, 468–470 (2004). https://doi.org/10.1023/B:BEBM.0000038155.56296.50

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  • DOI: https://doi.org/10.1023/B:BEBM.0000038155.56296.50

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