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Effect of Tetrachloromethane on the Immune System

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Abstract

Acute poisoning with tetrachloromethane in a dose of 0.75 LD50 suppressed humoral and cell immune reactions in Wistar rats. Immunotoxicity of tetrachloromethane is realized via initiation of lipid peroxidation and inhibition of acetylcholine esterase in T lymphocytes and α-naphthyl AS-acetate esterase and α-naphthyl butyrate esterase in splenocytes.

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Authors and Affiliations

  1. Saratov Military Institute of Radiational, Chemical, and Biological Protection, Saratov State Medical University, Saratov

    P. F. Zabrodskii, V. G. Germanchuk, V. F. Kirichuk & N. I. Karpenko

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  1. P. F. Zabrodskii
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  2. V. G. Germanchuk
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  3. V. F. Kirichuk
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  4. N. I. Karpenko
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Zabrodskii, P.F., Germanchuk, V.G., Kirichuk, V.F. et al. Effect of Tetrachloromethane on the Immune System. Bulletin of Experimental Biology and Medicine 137, 47–49 (2004). https://doi.org/10.1023/B:BEBM.0000024384.06935.91

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  • DOI: https://doi.org/10.1023/B:BEBM.0000024384.06935.91

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