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Cu,Zn-Superoxide Dismutase Gene Dosage and Cell Resistance to Oxidative Stress: A Review

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Abstract

It is well established that superoxide dismutase (SOD) is the irresplaceable enzyme for aerobic lifestyle. Our understanding of its role has made strides recently as the result of gene transfection approach. Available data on consequences of Cu,Zn-SOD gene transfection in cell resistance to oxygen toxicity are reviewed. There are data that increasing only Cu,Zn-SOD can be toxic, and the balance between Cu,Zn-SOD and peroxide-removing enzymes is supposed to be of prime importance in the antioxidant defence. Role of Cu,Zn-SOD deregulation in carcinogenesis is discussed.

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REFERENCES

  1. McCord, J. M. and Fridovich, I. (1969) J. Biol. Chem. 244:6049–6055.

    PubMed  Google Scholar 

  2. Fridovich, I. (1986) Methods Enzymol. 58:61–97.

    Google Scholar 

  3. Fridovich, I. (1989) J. Biol. Chem. 264:7761–7764.

    PubMed  Google Scholar 

  4. Hassan, H. M. (1988) Free Radical Biol. Med. 5:377–385.

    Google Scholar 

  5. Touati, D. (1988) Free Radical Biol. Med. 5:393–402. au]6._Superoxide Dismutases, (1985) Ed. L. W. Oberley, CRC Press, Inc., Boca Raton, Fl.

    Google Scholar 

  6. Kyle, M. E., Nakae, D., Sakaida, I., Miccadei, S. and Fraber, J. L. (1988) J. Biol. Chem. 263:3784–3789.

    PubMed  Google Scholar 

  7. Peskin, A. V., Koen, Y. M., Zbarsky, I. B. and Konstantinov, A. A. (1977) FEBS Lett. 78:41–45.

    PubMed  Google Scholar 

  8. Oberley, L. W. and Buettner, G. R. (1979) Cancer Res. 39:1141–1149.

    PubMed  Google Scholar 

  9. Bartoli, G. M., Bartoli, S., Galeotti, T. and Bertoli, E. (1980) Biochim. Biophys. Acta 620:205–211.

    PubMed  Google Scholar 

  10. Marklund, S. L., Westman, N. G., Lundgren, E. and Roos, G. (1982) Cancer Res. 42:1955–1961.

    PubMed  Google Scholar 

  11. Bannister, W. H., Federici, G., Heds, G. K. and Bannister, J. V. (1986) Free Rad. Res. Commun. 1:361–368.

    Google Scholar 

  12. Galeotti, T., Wohlrad, H., Borrello, S. and De Leo M. E. (1989) Biochem. Biophys. Res. Comm. 165:581–589.

    PubMed  Google Scholar 

  13. Fernandez-Pol, J. A., Hamilton, P. D. and Klos, D. J. (1982) Cancer Res. 42:609–617.

    PubMed  Google Scholar 

  14. Natvig, D. O., Imlay, K., Touati, D. and Hallewell, R. (1987) J. Biol. Chem. 262:14697–14701.

    PubMed  Google Scholar 

  15. Elroy-Stein, O., Bernstein, Y. and Groner, Y. (1986) EMBO J. 5:615–622.

    PubMed  Google Scholar 

  16. Krall, J., Bagley, A., Mullenbach, G., Hallewell, R. and Lynch, R. (1988) J. Biol. Chem. 263:1910–1914.

    PubMed  Google Scholar 

  17. Kelner, M. J. and Bagnell, R. (1990) J. Biol. Chem. 265:10872–10875.

    PubMed  Google Scholar 

  18. Brooksbank, B. W. L. and Balazs, G. (1984) Dev. Brain Res./Brain. Res. 16/318:37–44.

    Google Scholar 

  19. Sinet, P. M. (1982) Ann. N.Y. Acad. Sci. 396:83–94.

    PubMed  Google Scholar 

  20. Lieman-Hurwitz, J., Dafni, N., Lavie, V. and Groner, Y. (1982) Proc. Natl. Acad. Sci. 79:2808–2811.

    PubMed  Google Scholar 

  21. Epstein, C. J., Avraham, K. B., Lovett, M., Smith, S., Elroy-Stein, O., Rotman, G., Bry, C. and Groner, Y. (1987) Proc. Natl. Acad. Sci. USA 84:8044–8048.

    PubMed  Google Scholar 

  22. Elroy-Stein, O. and Groner, Y. (1988) Cell 52:259–267.

    PubMed  Google Scholar 

  23. Avraham, K. B., Schickler, M., Sapoznikov, D., Yrom, R. and Groner, Y. (1988) Cell 54:823–829.

    PubMed  Google Scholar 

  24. Groner, Y., Elroy-Stein, O., Avraham, K., Yarom, R., Schickler, M., Knobler, H. and Rotman, G. (1990) J. Physiol. (Paris) 84:53–77.

    Google Scholar 

  25. Peled-Komar, M., Lotem, J., Okon, E., Sachs, L. and Groner, Y. (1995) EMBO J. 14:4985–4993.

    PubMed  Google Scholar 

  26. Amstad, P., Peskin, A., Shah, G., Mirault, M.-E., Moret, R., Zbinden, I. and Cerutti, P. (1991) Biochemistry 30:9305–9313.

    PubMed  Google Scholar 

  27. Amstad, P., Moret, R. and Cerutti, P. (1994) J. Biol. Chem. 269:1606–1609.

    PubMed  Google Scholar 

  28. Buscigllo, J. and Yankner, B. A. (1995) Nature 378:776–779.

    PubMed  Google Scholar 

  29. De Haan, J. B., Cristiano, F., Iannello, R., Bladier, Kelner, M. J. and Kola, I. (1996) Human Mol. Gen. 5:283–292.

    Google Scholar 

  30. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. and Elledge, S. J. (1993) Cell 75:805–816.

    PubMed  Google Scholar 

  31. Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M. and Smith, J. R. (1994) Exp. Cell Res. 211:90–98.

    PubMed  Google Scholar 

  32. Michiels, C., Raes, M., Azchary, M. D., Delaive, E. and Remacle, C. (1988) Exp. Cell Res. 179:581–589.

    PubMed  Google Scholar 

  33. Peskin, A. V., Zbarsky, I. B. and Konstantinov, A. A. (1976) Dokl. Adad. Nauk SSSR 229:751–754.

    Google Scholar 

  34. Oberley, L. W., Oberley, T. D. and Buettner, G. R. (1980) Med. Hypoth. 6:249–268.

    Google Scholar 

  35. Oberley, L. W. and Oberley, T. D. (1984) J. Theor. Biol. 106:403–422.

    PubMed  Google Scholar 

  36. Cobbs, C. S., Levi, D. S., Aldape, K. and Israel, M. A. (1996) Cancer Res. 56:3192–3195.

    PubMed  Google Scholar 

  37. Oberley, L. W. and Spitz, D. R. (1984) Methods Enzymol. 105:457–464.

    PubMed  Google Scholar 

  38. Ysebaert-Vanneste M. and Vanneste W. H. (1980) Anal. Biochem. 107:86–96.

    PubMed  Google Scholar 

  39. Liochev, S. I., Batinichaberle, I. and Fridovich, I. (1995) Arch. Biochem. Biophys. 324:48–52.

    PubMed  Google Scholar 

  40. Wong, G. H. W., Elwell, J. H., Oberley, L. W. and Goeddel, D. V. (1989) Cell 58:923–931.

    PubMed  Google Scholar 

  41. Hockenbery, D. M., Oltvai, Z. N., Yin, X.-M., Milliman, C. L. and Korsmeyer, S. J. (1993) Cell. 75:241–251.

    PubMed  Google Scholar 

  42. Crapo, J. D. and Tierney, D. F. (1974) Am. J. Physiol. 226:1401–1407.

    PubMed  Google Scholar 

  43. Norris, K. and Hornsby, P. (1990) Mutat. Res. 237:95–106.

    PubMed  Google Scholar 

  44. Hodgson, E. and Fridovich, I. (1975) Biochemistry 14:5299–5303.

    PubMed  Google Scholar 

  45. Yim, M. B., Chock, P. B. and Stadman, E. R. (1993) J. Biol. Chem. 268:4099–4105.

    PubMed  Google Scholar 

  46. Beckman, J. S., Carson, M., Smith, C. D. and Koppenol, W. H. (1993) Nature 364:584–587.

    PubMed  Google Scholar 

  47. Peskin, A. V., Koen, Y. M. and Zbarsky, I. B. (1981) Molec. Biol. Rep. 7:25–30.

    Google Scholar 

  48. Kindas-Mugge, I. and Sauermann, G. (1985) Eur. J. Biochem. 148:49–54.

    PubMed  Google Scholar 

  49. Schroeder, H. C., Messer, R., Bachmann, M., Bernd, A. and Mueller, W. E. G. (1987) Mech. Ageing Dev. 41:251–266.

    PubMed  Google Scholar 

  50. Miesel, R., Mahmood, N. and Weser, U. (1995) Redox Rep. 1:99–103.

    Google Scholar 

  51. Troy, C. M. and Schelanksi, M. L. (1994) Proc. Natl. Acad. Sci. USA 91:6384–6387.

    PubMed  Google Scholar 

  52. Rothstein, J. D., Bristol, L. A., Hosier, B., Brown, R. H. and Kuncl, R. W. (1994) Proc. Natl. Acad. Sci, USA 91:4155-4159.

    Google Scholar 

  53. Troy, C. M. and Schelanksi, M. L. (1994) Proc. Natl. Acad. Sci. USA 91:6384-6387.

    PubMed  Google Scholar 

  54. Mao, G., Thomas, P., Lopaschuk, G. and Poznansky, M. (1993) J. Biol. Chem. 268:416-420.

    PubMed  Google Scholar 

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  1. Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 117808, Russia

    Alexander V. Peskin

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Peskin, A.V. Cu,Zn-Superoxide Dismutase Gene Dosage and Cell Resistance to Oxidative Stress: A Review. Biosci Rep 17, 85–89 (1997). https://doi.org/10.1023/A:1027343519591

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