Abstract
Our aim was to determine sites of substance Pbinding in the gut of the BB rat and examine changes inSP binding in the diabetic rat, over time. Specificbinding of [125I]substance P was localized insections of nondiabetic gut using emulsionautoradiography and quantitated in diabetic andnondiabetic gut using film autoradiography. High levelsof SP binding were located in esophageal muscularismucosa, circular muscle of the stomach and colon, deep muscularplexus, and in the circular muscle adjacent to theplexus in the ileum. The myenteric plexus demonstratedmoderate to high levels of binding. Specific binding increased in the antrum and pylorus at threeweeks and in the jejunum and distal colon at four weeksof diabetes but decreased in the distal ileum at two tofour weeks of diabetes. Changes persisted at four to six months. These results contribute tounderstanding changes in the control of intestinalmotility in diabetes.
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Yu, O., Ouyang, A. Substance P Binding in Gastrointestinal Tract of Nondiabetic BB Rat and Changes in Diabetic BB Rat over Time. Dig Dis Sci 44, 749–755 (1999). https://doi.org/10.1023/A:1026665926242
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DOI: https://doi.org/10.1023/A:1026665926242