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Protective Effect of Enriched Diet Plus Growth Hormone Administration on Radiation-Induced Intestinal Injury and on Its Evolutionary Pattern in the Rat

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Abstract

Adequate nutritional support can enhance theprotective action of growth hormone in radiation-inducedmucositis. Our aim is to address the evolutionarypattern of radiation injury to the small intestine of rats fed a high-protein diet and treatedwith growth hormone before irradiation. Male Wistar ratswere fed a high-protein diet and killed two, four orseven days after irradiation. Animals were given either growth hormone or saline. Thecombination of growth hormone and high-protein dietreduced mortality, increased mucosal height and cryptproliferation, and reduced apoptosis from day 2 to day7 after irradiation. Bacterial translocation wasincreased in rats fed the high-protein formula.Insulin-like growth factor was reduced by radiation andfurther reduced by the high-protein diet. Thecombination of growth hormone and high-protein dietprotects from the damage caused by radiation to thebowel and accelerates its recovery. This effect does notseem to be mediated through insulin-like growth factor levels.

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Authors
  1. Isabel Vazquez
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  2. Ignacio A. Gomez-De-Segura
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  3. Antonio G. Grande
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  4. Ana Escribano
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  5. Pilar Gonzalez-Gancedo
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  6. Alicia Gomez
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  7. Rosa Diez
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  8. Enrique De Miguel
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Vazquez, I., Gomez-De-Segura, I.A., Grande, A.G. et al. Protective Effect of Enriched Diet Plus Growth Hormone Administration on Radiation-Induced Intestinal Injury and on Its Evolutionary Pattern in the Rat. Dig Dis Sci 44, 2350–2358 (1999). https://doi.org/10.1023/A:1026637611298

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