Abstract
This study investigates the effects of ilealautotransplantation on morphology, crypt cellproliferation, and brush border disaccharidases of theremaining jejunoileum and colon in growing pigs with 75% proximal small bowel resection. Resection wasperformed on 30 pigs, of which 15 underwent anautotransplantation of the remaining ileum. Theautotransplanted pigs showed reduced weight gain andremnant ileal length when compared to the resectedcontrols. In the autotransplanted pigs, small boweldiameter and weight, mucosal weight and protein content,villus height and surface area, crypt depth, and the number of proliferating crypt cells werereduced similarly both in the intact jejunum and in theautotransplanted ileal remnant. Autotransplantation alsodecreased the number of proliferative crypt cells of the colon. Specific activities of maltaseand sucrase tended to increase in the autotransplantedileal remnant, whereas the total enzyme activitiesdecreased. These results suggest that ilealautotransplantation disturbs postresectional adaptation of theremaining gut.
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Lauronen, J., Pakarinen, M.P., Kuusanmaki, P. et al. Synchronous Ileal Autotransplantation Impairs Adaptation of Remaining Gut in Pigs with Proximal Small Bowel Resection. Dig Dis Sci 44, 2187–2195 (1999). https://doi.org/10.1023/A:1026636216324
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DOI: https://doi.org/10.1023/A:1026636216324