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Adhesion of bone cells to ion-implanted titanium

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Abstract

The use of ion-implantation to encourage osseointegration has been investigated using an in vitro model cell culture system and surface analysis. Polished titanium discs were implanted with calcium, potassium and argon ions. The adhesion of bone-derived cells was measured using radioactively labeled cells and the morphology examined using scanning electron microscopy. Similar numbers of cells were found to adhere to the potassium and argon-implanted titanium as to control (non-implanted) titanium. However, adhesion to the calcium-implanted titanium discs was significantly reduced. Moreover, although the cells were found to be well spread on the calcium and potassium-implanted titanium, a much greater proportion of cells appeared to remain rounded and poorly attached on the argon-implanted surface. These differences are discussed in relation to the observed surface roughness and chemistry, which were assessed using interferometry and X-ray photoelectron spectroscopy, respectively.

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Authors and Affiliations

  1. Departments of Biomaterials and Periodontology, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    S. Nayab, I. Olsen & F. H. Jones

  2. Departments of Periodontology and Prosthetic Dentistry, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    L. Shinawi

  3. Department of Prosthetic Dentistry, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    J. Hobkirk

  4. Department of Electrical and Electronic Engineering, Imperial College of Science, Technology and Medicine, Exhibition Road, London, SW7 2BT, UK

    T. J. Tate

Authors
  1. S. Nayab
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  2. L. Shinawi
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  3. J. Hobkirk
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  4. T. J. Tate
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  5. I. Olsen
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  6. F. H. Jones
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Correspondence to I. Olsen.

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Nayab, S., Shinawi, L., Hobkirk, J. et al. Adhesion of bone cells to ion-implanted titanium. Journal of Materials Science: Materials in Medicine 14, 991–997 (2003). https://doi.org/10.1023/A:1026358917896

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