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Fed-batch fermentation of Lactobacillus lactis for hyper-production of l-lactic acid

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Abstract

A fed-batch fermentation of Lactobacillus lactis to produce l-lactic acid was developed in which the residual glucose concentration in the culture was used to control a continuous feeding strategy. Up to 210 g l-lactic acid l−1 (97% yield) was obtained. The maximal dry cell was 2.7 g l−1 and the average l-lactic acid productivity was 2.2 g l−1 h−1.

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Authors and Affiliations

  1. Department of Biochemical Engineering, School of Chemical Engineering & Technology, P.R. China

    Dong-Mei Bai & Qiang Wei

  2. National Engineering Research Center for Distillation Technology, Tianjin University, Tianjin, 300072, P.R. China

    Dong-Mei Bai, Qiang Wei & Xin-Gang Li

  3. Department of Biochemical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin, 300072, P.R. China

    Zhi-Hui Yan, Xue-Ming Zhao & Shi-Min Xu

Authors
  1. Dong-Mei Bai
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  2. Qiang Wei
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  3. Zhi-Hui Yan
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  4. Xue-Ming Zhao
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  5. Xin-Gang Li
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  6. Shi-Min Xu
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Correspondence to Xue-Ming Zhao.

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Bai, DM., Wei, Q., Yan, ZH. et al. Fed-batch fermentation of Lactobacillus lactis for hyper-production of l-lactic acid. Biotechnology Letters 25, 1833–1835 (2003). https://doi.org/10.1023/A:1026276925649

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  • DOI: https://doi.org/10.1023/A:1026276925649

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