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Comparison of Three Inbred Mouse Strains with Respect to General and Genetic Radiosensitivity

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Abstract

The radiosensitivities of three mouse strains (BALB/cLacY, C3H/SnY, and 101/HY) have been compared using the following parameters: survival after irradiation at a dose of 6–7 Gy, chromosome aberration frequency in bone marrow cells after irradiation at a dose of 1.5 Gy, and the change in testis weight and frequency of abnormal sperm heads (ASHs) after irradiation at doses from 0.5 to 4 Gy. Strain BALB/c is the most radiosensitive with respect to the survival and chromosome aberration frequency in the bone marrow but the most resistant with respect to the change in testis weight and the frequency of abnormal sperm heads. Strain 101/HY was the most resistant with respect to survival and chromosome aberration frequency in bone marrow after irradiation but the most radiosensitive with respect to testis damage.

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Authors and Affiliations

  1. Research Laboratory for Experimental Biological Models, Svetlye Gory, Moscow oblast, 143440, Russia

    A. M. Malashenko & T. B. Beskova

  2. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    M. D. Pomerantseva & L. K. Ramaiya

Authors
  1. A. M. Malashenko
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  2. T. B. Beskova
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  3. M. D. Pomerantseva
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  4. L. K. Ramaiya
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Malashenko, A.M., Beskova, T.B., Pomerantseva, M.D. et al. Comparison of Three Inbred Mouse Strains with Respect to General and Genetic Radiosensitivity. Russian Journal of Genetics 39, 1052–1055 (2003). https://doi.org/10.1023/A:1025731319338

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  • DOI: https://doi.org/10.1023/A:1025731319338

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